Feasibility, efficacy and cosmetic effect of three-dimensional conformal external beam partial breast irradiation for the selected early stage breast cancer patients after breast-conserving surgery

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Author:
XU Min(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
ZUO Wen-shu()
LI Jian-bin(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
FAN Ting-yong(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
SHAO Qian(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
LU Jie(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
WANG Chun-xiang(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
XING Jun(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
ZHANG Ying-jie(Department of Radiation Oncology, Shandong Tumor Hospital & Institute;Shandong Provincial Key Laboratory of Radiation Oncology Shandong Academy of Medical Sciences Ji'nan 250117, China)
WANG Yong-sheng()
Journal Title:
Chinese Journal of Radiation Oncology
Issue:
Volume 21, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1004-4221.2012.05.014
Key Word:
Breast neoplasms/surgery;Surgery, breast-conserving treatment;Breast neoplasms/radiotherapy;Radiotherapy, three-dimensional conformal;Radiotherapy, partial breast;Prognosis

Abstract: Objective To explore the feasibility,efficacy and cosmetic effect of three-dimensional conformal external beam partial breast irradiation (EB-PBI) after breast-conserving surgery for the selected Chinese early stage breast cancer patients.Methods From June 2003 to December 2010,Forty-four early stage breast cancer patients underwent EB-PBI after breast-conserving surgery.Twenty patients had CT simulation scan in moderate deep inspiration breathing hold,and twenty-four patients in free breathing.EB-PBI was planned and delivered by three-dimensional conformal radiotherapy (3DCRT) with four noncoplanar beams.The prescribed dose was 3.40 Gy per fraction in thirty-nine patients and 3.85 Gy per fraction in five patients,twice per day at an interval of at least six hours,in five consecutive days.Results The number of patients with follow up time of 2,3 and 5 years were 39,31 and 16.Grade 1 acute radiationinduced dermatitis was observed in 17 patients (39%) at three months.Cosmesis was good or excellent in all cases at six months after radiotherapy and in 95% cases at two years after radiotherapy.The 2-,3-and 5-year local control rates were 100%,99% and 94%,respectively.The 2-,3-,and 5-year survival rates were all 100% and no metastases occurred.Conclusions EB-PBI delivered by 3DCRT is feasible for selected Chinese early stage breast cancer patients after breast-conserving surgery.The cosmetic effect,local control rate and long-term survival rate are satisfactory,and acute radiation toxicity is very low.

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