Treatment outcomes of 792 cases of esophageal carcinoma patients treated with three-dimensional radiotherapy

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Author:
KONG Jie(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
LI Xiao-ning(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
HAN Chun(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
WANG Lan(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
GAO Chao(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
ZHANG Jing(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
TIAN Hua(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
XIAO Ai-qin(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
MA Guo-xin(Department of Radiation Oncology, Fourth Hospital of Hebei Medical University,Shijiazhuang 050011, China)
Journal Title:
Chinese Journal of Radiation Oncology
Issue:
Volume 21, Issue 05, 2012
DOI:
10.3760/cma.j.issn.1005-4221.2012.05.007
Key Word:
Esophageal neoplasms/three-dimensional radiotherapy;Three-dimensional radiotherapy, conformal;Three-dimensional radiotherapy, intensity-modulated;Prognosis

Abstract: Objective To investigate the long term clinical result of three-dimensional radiotherapy for esophageal carcinoma,discuss the effect of correlative factors to survival and local control.Methods From July 2003 to December 2008,792 patients with esophageal cancer were eligible.Patients were treated with three-dimensional radiotherapy (672 patients) or intensity-modulated (120 patients) radiotherapy.The radiotherapy was delivered in 1.8-2.0 Gy per fraction,5 fractions per week,total dose of 50-70 Gy,(median,60 Gy).142 patients were treated by concurrent radiochemotherapy,and the other 650 patients radiotherapy alone.The local control rate and survival rate were calculated by Kaplan-Meier method.Logrank method was used for univariate analyses.Cox regression model was used for multivariate analyses.Results The follow-up rate was 95.8%.The number of patients with 5 years time followed-up was 133.The 1-year,3-year and 5-year local control rates were 76.6%,53.2%,48.6%,and the 1-year,3-year and 5-year overall survival rates were 70.1%,36.7% and 28.0%,respectively.There were significant influence on the prognosis of T stage,N stage,TNM stage,tumor volume ( x2 =20.58-55.60,all P =0.000).The Cox multivariate model showed that N stage and tumor volume were independent prognostic factors (x2 =6.35,29.23,P =0.012,0.000).For the two groups of concurrent chemo-radiotherapy and radiotherapy alone,5-year local control rates were 57.0% and 46.8% ( x2 =7.34,P =0.007 ),the 5-year overall survival rate 32.8% and 27.6% ( x2 =3.42,P =0.064.Conclusions Three-dimensional radiotherapy is effective for esophageal carcinoma.It might improve the local control rate and overall survival rate to some extent.T staging,N staging,TNM staging and tumor volume were important prognostic factors for long-term survival.The addition of concurrent radiochemotherapy could improve local control rates.

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