Variation of gross tumor volume and clinical target volume definition for lung cancer
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 4
- DOI:
- 10.3760/cma.j.issn.1004-4221.2011.04.006
- Key Word:
- 肺肿瘤/放射疗法;大体肿瘤体积;临床靶体积;系统误差;Lung neoplasms/radiotherapy;Gross tumor volume;Clinical target volume;System error
Abstract： Objective To study the variation of gross tumor volume (GTV) and clinical target volume (CTV) definition for lung cancer between different doctors.Methods Ten lung cancer patients with PET-CT simulation were selected from January 2008 to December 2009.GTV and CTV of these patients were defined by four professors or associate professors of radiotherapy independently.Results The mean ratios of largest to smallest GTV and CTV were 1.66 and 1.65, respectively.The mean coefficients of variation for GTV and CTV were 0.20 and 0.17, respectively.System errors of CTV definition in three dimension were less than 5 mm, which was the largest in inferior and superior (0.48 cm,0.37 cm,0.32 cm;F=0.40,0.60,0.15,P=0.755,0.618,0.928).Conclusions The variation of GTV and CTV definition for lung cancer between different doctors exist.The mean ratios of largest to smallest GTV and CTV were less than 1.7.The variation was in hilar and mediastinum lymphanode regions.System error of CTV definition was the largest (<5 mm) in cranio-caudal direction.
- [1]王凯,王绿化,梁军,等.FDG PET对非小细胞肺癌合并肺不张三维适形放疗时靶区确定的临床意义[J].2006,(1).
- [2]Balogh JM,Ung YC,Ganguli SN,etc.Observer variation in contouring gross tumor volume in patients with poorly defined non-small-cell lung tumors on CT: the impact of 18FDG-hybrid PET fusion.[J].2001,51(4).
- [3]C H, Ketting,M, Austin-Seymour,I, Kalet,etc.Consistency of three-dimensional planning target volumes across physicians and institutions.[J].1997,37.
- [4]Ishikura S,van Sornsen de Koste JR,Casas F,etc.Variations in target volume definition for postoperative radiotherapy in stage III non-small-cell lung cancer: analysis of an international contouring study.[J].2010,76(4).
- [5]Millward M,Fisher R,McKenzie A,etc.Measurement of lung tumor volumes using three-dimensional computer planning software.[J].2002,53(3).
- [6]Freudenberg LS,Antoch G,Rosenbaum SJ,etc.PET versus PET/CT dual-modality imaging in evaluation of lung cancer.[J].2007,45(4).
- [7]Van de Steene J,Linthout N,de Mey J,etc.Definition of gross tumor volume in lung cancer: inter-observer variability.[J].2002,62(1).
- [8]Bova D,Halama J,Sethi A,etc.Correlation of PET standard uptake value and CT window-level thresholds for target delineation in CT-based radiation treatment planning.[J].2007,67(3).
- [9]Grills IS,Martinez AA,Wong CY,etc.Defining a radiotherapy target with positron emission tomography.[J].2004,60(4).
- [10]Wasserman ToddH,Bradley JeffreyD,Ieumwananonthachai Nantaken,etc.Gross tumor volume, critical prognostic factor in patients treated with three-dimensional conformal radiation therapy for non-small-cell lung carcinoma.[J].2002,52(1).
- [11]Lagerwaard FJ,Schmitz P,Samson M,etc.Evaluation of a target contouring protocol for 3D conformal radiotherapy in non-small cell lung cancer.[J].1999,53(3).
- [12]Giraud P,Elles S,Helfre S,etc.Conformal radiotherapy for lung cancer: different delineation of the gross tumor volume (GTV) by radiologists and radiation oncologists.[J].2002,62(1).