The predictive value of 1H-MRS and DWI in low-grade cerebral astrocytomas

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BAI Yu-zhen(Department of MR, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050,China)
NIU Guang-ming(Department of MR, Affiliated Hospital of Inner Mongolia Medical College, Hohhot 010050,China)
Journal Title:
Volume 20, Issue 01, 2011
Key Word:
Proton magnetic resonance spectroscopy;Diffusion weighted imaging;Astrocytomas;Radiotherapy

Abstract: Objective To evaluate the predictive value of proton magnetic resonance spectroscopy (1H-MRS)and diffusion weighted imaging(DWI)in low-grade cerebral astrocytomas. Methods Twenty patients with histological proved low-grade astrocytomas treated with postoperative radiotherapy were evaluated with cMRIMRS, DWI before-and 3 months after radiotherapy respectively, then repeated every six months. rNAA,rCho,rCr,rADC was the ratio of NAA, Cho and Cr in the residual tumors region to the those of normal control region. The difference of rCho/rCr, rCho/rNAA, rADC between deteriorative group(group Ⅰ)and stable groups(group Ⅱ)were calculated both before-and 3months after radiotherapy. Results The value of rCho/rCr, rCho/rNAA were higher in group 1 than those in group Ⅱ 3 months after radiotherapy(t =3.65 and 4. 24,all P < 0. 05), while the value of rADC was lower in group Ⅰ(t = 3.43, P < 0. 05). The mean difference of rCho/rCr,rCho/rNAA, rADC in group Ⅰ were smaller than those in group Ⅱ(t = 2. 02,4. 21 and 3.00,all P <0. 05). The value of rCho/rCr,rCho/rNAA increased and rADC decreased gradually in group Ⅰ during follow up, and these patients were histologically proved recurrence within 11 - 16 months.While in group Ⅱ , the value of rCho/rCr, rCho/rNAA decreased and rADC increased gradually or steady.And also with a stable clinical performance and cMRI. Conclusions 1H-MRS and DWI own better predictive value of monitoring tumor metabolism change, growth potential and evaluation response to radiotherapy than conventional MRI in low-grade group astrocytomas.

  • [1]朱广迎,姜平,罗京伟.颅内肿瘤//朱广迎.放射肿瘤学.2版.北京:科学技术文献出版社,2007:205.
  • [2]蒋晓东,史良玉,宋大安,等.氢质子磁共振波谱在颅内肿瘤放疗效果评价中的应用研究.中华放射肿瘤学杂志,2007,16:42-44.
  • [3]Isobe T,Matsumura A,Anno I,et al.Changes in 1H-MRS in glioma patients before and after irradiation:the significance of quantitative analysis of choline-containing compounds.No Shinkei Geka,2003,31:167-172.
  • [4]Law M,Cha S,Knopp EA,et al.High grade gliomas and solitary metastases; differentiation by using perfusion and proton spectroscopy MR imaging.Radiology,2002,222:715-721.
  • [5]Burtscher IM,Skagerberg G,Geijer B,et al.Proton MR spectroscopy and preoperative diagnostic accuracy:an evaluation of intracranial masslesions characterized by stereotactic biopsy findings.AJNR,2000,21:84-93.
  • [6]Nail B,Inanc G,Onder O,et al.The added value of the apparent diffusion coefficient calculation to magnetic resonance imaging in the differentiation and grading of malignant brain tumors.J Comput Assist Tomogr,2004,28:735-746.
  • [7]Provenzale JM,Engelter ST,Petrella JR,et al.Use of MR exponential diffusion weight edimagesto eradicate T2" shinethrough" effect.AJR,1999,172:537-539.
  • [8]Laprie A,Pirzkall A,Haas-Kogan DA,et al.Longitudinal multivoxel MR spectroscopy study of pediatric diffuse brainstem gliomas treated with radiotherapy.Int J Radiat Oncol Biol Phys,2005,62:20-31.
  • [9]Schlemmer HP,Bachert P,Henze M,et al.Differentiation of radiation necrosis from tumor progression using proton magnetic resonance spectroscopy.Neuroradiology,2002,44:216-222.
  • [10]Calvar JA,Meli FJ,Romero C,et al.Characterization of brain tumors by MRS,DWI and Ki-67 labeling index.J Neurooncol,2005,72:273-280.
  • [11]Tarnawski R,Sokol M,Pieniazek P,et al.1H-MRS in vivo predicts the early treatment outcome of postoperative radiotherapy for malignant gliomas.Int J Radiat Oncol Biol Phys,2002,52:1271-1276.
  • [12]Rand SD,Krouwer HG.MRS imaging of gamma knife treatment for gliomas:from metabolite ratios to therapeutic rationale Am J Neuroradiol,2007,22:598-599.
  • [13]孙彦辉.脑胶质瘤治疗标准及最新进展.中国微侵袭神经外科杂志,2006,11:337.
  • [14]徐庆中.中枢神经系统肿瘤//刘彤华.诊断病理学.2版.北京:人民卫生出版社,2006:913-914.
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