Comparative study of treatment planning between intensity - modulated arc therapy and simultaneously integrated boost intensity-modulated radiotherapy in nasopharyngeal carcinoma
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 6
- DOI:
- 10.3760/cma.j.issn.1004-4221.2010.06.002
- Key Word:
- 鼻咽肿瘤/放射疗法;放射疗法,调强;放射疗法,旋转调强;放射疗法,同步加量;剂量学;Nasopharyngeal neoplasms/radiotherapy;Radiotherapy,intensity-modulated;Radiotherapy,intensity-modulated arc;Radiotherapy,simultaneously integrated boost;Dosimetry
Abstract： Objective To compare the dosimetric differences of target volume and organ at risk between intensity-modulated arc therapy (IMAT) and simultaneously integrated boost intensity-modulated radiotherapy (SIB-IMRT) in nasopharyngeal carcinoma. Methods IMAT and SIB-IMRT treatment plans of 10 nasopharyngeal carcinoma cases were generated by Varian Eclipse ver8. 6 treatment planning system. The dosimetric parameters of target volume and organ at risk (OAR), the monitor units (MU) and treatment time were compared between IMAT and SIB-IMRT treatment plan. Results The conformal index ( CI ) of PTV, PTV1, PTV2 of IMAT and SIB-IMRT were 0. 71 and 0. 75 ( Z = - 2. 32, P ＜ 0. 05 ), 0. 54 and 0. 59 (Z= -2.56,P＜0.05), 0.71 and 0.78(Z= -2.52,P＜0.05), respectively. the homogenous index (HI) of PTV, PTV1, PTV2 of IMAT and SIB-IMRT were 10.5 and 11.2(Z= -0. 84,P＞0.05),13. 1 and 17. 1(Z= -1.68,P＞0.05) and 14. 1 and 13.3(Z= -1. 01,P＞0.05) respectively;the brain-stem mean does were 3512. 8 cGy ± 406. 2 cGy and 3384. 3 cGy ± 361.3 cGy ( Z= - 1.82, P ＞ 0. 05 ); the brain-stem maximum dose were 5528. 1cGy ± 192. 9 cGy and 5727. 5 cGy ± 356. 3 cGy ( Z = - 1.12, P ＞ 0. 05 ); the maximum dose of spinal-cord were were 4186. 1cGy ± 88.7 cGy and 4390. 2 cGy ± 74. 9 cGy ( Z =-2. 38 ,P ＜ 0. 05 ). There were no significant differences between parotid dose and normal tissue ( P ＞0. 05. ) MU were 606 ± 96 and 1308 ± 213 for IMAT and SIB-IMRT ( Z= - 2. 52, P ＜ 0. 05 ). Conclusions The IMAT plan showed a better conformal index than SIB-IMRT plan, with the same dosimetric parameters of the target volume and OAR. The IMAT plan could reduce normal tissues dose, monitor units and treatment time in the treatment of nasopharyngeal carcinoma.
- [1]袁智勇,高黎,徐国镇,等.初治鼻咽癌调强放疗的初步结果[J].2006,(4).
- [2]金大伟,戴建荣,李晔雄,等.前列腺癌调强放疗的治疗方案比较[J].2005,(1).
- [3]赵充,卢泰祥,韩非,等.139例鼻咽癌调强放疗的临床研究[J].2006,(1).
- [4]Fogliata A,Clivio A,Franzetti Pellanda A.Volumetric-modulated arc radiotherapy for carcinomas of the anal canal: A treatment planning comparison with fixed field IMRT.[J].2009,92(1).
- [5]Mahantshetty U,Jamema SV,Fogliata A,etc.A treatment planning study comparing volumetric arc modulation with RapidArc and fixed field IMRT for cervix uteri radiotherapy.[J].2008,89(2).
- [6]Vanetti, Eugenio,Nicolini, Giorgia,Fogliata, Antonella,etc.Intensity modulation with photons for benign intracranial tumours: A planning comparison of volumetric single arc, helical arc and fixed gantry techniques[J].2008,89(3).
- [7]Mohan R,Schmidt Ullrich R,Wu Q,etc.Simultaneous integrated boost intensity-modulated radiotherapy for locally advanced head-and-neck squamous cell carcinomas. I: dosimetric results.[J].2003,56(2).
- [8]Otto K.Volumetric modulated arc therapy: IMRT in a single gantry arc.[J].2008,35(1).
- [9]McKenzie M,Shaffer R,Otto K,etc.Volumetric modulated arc therapy for delivery of prostate radiotherapy: comparison with intensity-modulated radiotherapy and three-dimensional conformal radiotherapy.[J].2008,72(4).
- [10]Vanetti E,Clivio A,Nicolini G.Volumetric modulated arc radiotherapy for carcinomas of the oro-pharynx, hypo-pharynx and larynx: a treatment planning comparison with fixed field IMRT.[J].2009,92(1).
- [11]Yu CX..Intensity-Modulated ARC Therapy with Dynamic Multileaf Collimation - an Alternative to Tomotherapy[J].1995,40(9).
- [12]A, Brahme.Optimization of stationary and moving beam radiation therapy techniques.[J].1988,12.
- [13]De Neve W,De Gersem W,Boterberg T,etc.Clinical implementation of intensity-modulated arc therapy (IMAT) for rectal cancer.[J].2004,60(3).
- [14]Coghe M,De Neve W,De Gersem W,etc.Whole abdominopelvic radiotherapy (WAPRT) using intensity-modulated arc therapy (IMAT): first clinical experience.[J].2003,57(4).
- [15]Ohlhues L,Kjaer Kristoffersen F,Medin J,etc.RapidArc volumetric modulated therapy planning for prostate cancer patients.[J].2009,48(2).
- [16]B S, Teh,S Y, Woo,E B, Butler.Intensity modulated radiation therapy (IMRT): a new promising technology in radiation oncology.[J].1999,4.