FDG PET or PET-CT versus MRI in detecting local residue or recurrence of nasopharyngeal carcinoma after radiotherapy: a meta-analysis
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 5
- DOI:
- 10.3760/cma.j.issn.1004-4221.2010.05.002
- Key Word:
- 肿瘤残留或复发,鼻咽;体层摄影术,正电子发射,氟标记脱氧葡萄糖;磁共振成像;Neoplasm residue or recurrence,nasopharyngeal;Tomography,positron emissions,18F-labeled deoxyglucose;Magnetic resonance imaging
Abstract： Objective To compare the value of 18 F-labeled deoxyglucose (FDG) PET or PET-CT with MRI in detecting local residue or recurrence of nasopharyngeal carcinoma after radiotherapy, by performing a meta-analysis of relevant trials.Methods A literature search was performed to English original articles about FDG PET or PET-CT and MRI in Medline, Embase and the Cochrane database from January 1995 to August 2009.The reference standard was histopathologic analysis and/or close clinical and imaging follow-up.Two reviewers searched articles and extracted data independently.Sensitivity, specificity,summary receiver operating characteristic curves (SROC), and the Q index for FDG PET or PET-CT and MRI were pooled, respectively.Results Seventeen studies about FDG PET or PET-CT and 10 studies about MRI were included in this meta-analysis.The pooled sensitivity of FDG PET or PET-CT and MRI were 0.935(95% CI= 0.901 -0.964) and 0.792 (95% CI= 0.731 -0.844), separately.The pooled specificity were 0.924 (95 % CI= 0.898 - 0.945) and 0.787 (95 % GI= 0.746 - 0.825), separately.Area under SROC curves of PET-CT or PET (0.966) was significantly larger than that of MRI (0.852) (z =2.29, P < 0.05).The Q * index estimates for PET-CT or PET (0.914) were significantly higher than for MRI (0.783)(z=2.94,P<0.05).Conclusions FDG-PET/PET-CT has higher accuracy than MRI in diagnosing local residue or recurrence of nasopharyngeal carcinoma after radiotherapy.
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