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Value of 18FDG PET-CT after radiotherapy in nasopharyngeal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1004-4221.2007.06.002
- Key Word:
- 鼻咽肿瘤/放射疗法;病灶残留;断层摄影术,正电子发射型;断层摄影术,计算机
Abstract： 目的 研究18FDG PET-CT在鼻咽癌放疗后的应用价值.方法 27例鼻咽癌放疗后CT检查发现鼻咽黏膜增厚者在放疗后8～32周行全身18FDG PET-CT检查,并在检查后对全部病例随访12个月以上,所有患者均行纤维鼻咽镜活检.利用PET-CT评价鼻咽癌在放疗后转移及残留,并分析SUV值与预后相关性.结果 27例中2例通过PET-CT检查发现远处转移,及时接受相应治疗.以SUV≥2.5作为阳性标准,PET-CT诊断鼻咽癌局部残留20例,其中经病理证实18例;诊断为局部低代谢性病灶7例,病理证实5例.18例被确诊为鼻咽癌局部残留者分别接受鼻咽腔内放疗或立体定向适形放疗.全组患者1年局部控制率为70%,1年总生存率为81%.SUV≥5者11例,1年局部控制率为55%,远处转移率为82%,1年生存率为64%.2.5≤SUV＜5者9例,1年局部控制率为67%,远处转移率为22%,1年生存率为89%.两者1年局部控制率和生存率比较差异无统计学意义(P=0.670、0.319),远处转移率差异有统计学意义(P=0.022).结论 18FDG PET-CT对于鉴别鼻咽癌患者放疗后病灶残留具有诊断意义,放疗后局部残留病灶SUV值与远处转移率有关.
- [1]陈应瑞,辜梅新,李伟雄,等.FDG PET判断鼻咽癌放疗后鼻咽病灶残留的临床价值[J].2002,(6).
- [2]郭洪波,于金明,朱慧,等.18F-脱氧葡萄糖PET-CT检测食管癌治疗后复发与转移的应用价值[J].2006,(6).
- [3]Kalff V,Hicks RJ,Drummond EG.Findings on 18F-FDG PET Scans After Neoadjuvant Chemoradiation Provides Prognostic Stratification in Patients with Locally Advanced Rectal Carcinoma Subsequently Treated by Radical Surgery.[J].2006,47(1).
- [4]Seethala RR,Ferris RL,Degirmenci B,etc.Posttreatment assessment of response using FDG-PET/CT for patients treated with definitive radiation therapy for head and neck cancers.[J].2006,65(5).
- [5]谷铣之... [等]主编.肿瘤放射治疗学[M].1993.
- [6]Williams DW 3rd,Keyes JW Jr,Watson NE,etc.Can post-rt neck dissection be omitted for patients with head-and-neck cancer who have a negative pet scan after definitive radiation therapy?[J].2004,58(3).
- [7]Dora L. W. Kwong M.B.B.S.,John Nicholls M.B.B.S.,William I. Wei M.S.,etc.The time course of histologic remission after treatment of patients with nasopharyngeal carcinoma[J].1999,85(7).
- [8]Dornfeld KJ,Graham SM,Chang K,etc.The role of FDG PET in management of neck metastasis from head-and-neck cancer after definitive radiation treatment.[J].2005,63(4).
- [9]Graeter TP,Hellwig D,Hellwig AP,etc.Diagnostic performance and prognostic impact of FDG-PET in suspected recurrence of surgically treated non-small cell lung cancer.[J].2006,33(1).
- [10]Davis LW,Koshy M,Howell R,etc.Comparison of CT- and FDG-PET-defined gross tumor volume in intensity-modulated radiotherapy for head-and-neck cancer.[J].2005,61(5).