You Position: Home > Paper
Probe into the clinical significance of target volume and change of the normal organs in image-guided radiotherapy for nasopharyngeal carcinoma
( views:381, downloads:264 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1004-4221.2007.02.001
- Key Word:
- 鼻咽肿瘤/放射疗法;调强放疗;图像引导放疗
Abstract： 目的 探讨鼻咽癌调强放疗(IMRT)中靶区和正常器官变化规律.方法 15例鼻咽癌初治患者接受全程IMRT,分别于计划设计前、治疗前、治疗25次时行3次CT扫描.第2、3次CT均和第1次cT行图像融合.3次CT图像的原发肿瘤(GTVnx)、GTVnx内气腔、腮腺、轮廓分别勾画,分析其变化规律.结果 治疗计划完成时,有2例患者GTVnx增大.照射至25次时,GTVnx缩小0～10.39 cm3(即GTV内气腔容积);腮腺体积缩小0.13～23.80 cm3;腮腺缩小程度与原体积大小有一定的相关性;腮腺外界向内侧移动,内界位置变化不大.头部轮廓横径均有不同程度缩小.结论 鼻咽癌患者在接受IMRT过程中,原发肿瘤体积、腮腺结构、位置、轮廓横径在一定程度发生变化,这可能会影响IMRT剂量分布,降低靶区、增加正常组织剂量,值得临床进一步研究.
- [1]袁智勇,高黎,徐国镇,等.初治鼻咽癌调强放疗的初步结果[J].2006,(4).
- [2]罗京伟,傅卫华,阎蒂,等.头颈部癌调强放疗过程中腮腺及靶区体积变化的临床分析[J].2006,(2).
- [3]Berry SL,Wolden SL,Chen WC,etc.Intensity-modulated radiation therapy (IMRT) for nasopharynx cancer: update of the Memorial Sloan-Kettering experience.[J].2006,64(1).
- [4]H, Huizenga,P C, Levendag,P M, De Porre,etc.Accuracy in radiation field alignment in head and neck cancer: a prospective study.[J].1988,11(2).
- [5]Naczk E,Jassem J,Senkus Konefka E,etc.Changes in lateral dimensions of irradiated volume and their impact on the accuracy of dose delivery during radiotherapy for head and neck cancer.[J].2006,79(3).
- [6]Lee N,Poon I,Akazawa P,etc.Intensity-modulated radiotherapy in the treatment of nasopharyngeal carcinoma: an update of the UCSF experience.[J].2002,53(1).