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Primary observing pulmonary function variety following three-dimensional conformal radiation therapy of Ⅲ phase non-small cell lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1004-4221.2006.06.003
- Key Word:
- 癌,非小细胞肺/放射疗法;三维适形放疗;肺功能;剂量体积直方图参数;放射性肺炎
Abstract： 目的 探讨Ⅲ期非小细胞肺癌三维适形放疗前后肺功能、DVH参数与放射性肺炎发生程度的关系.方法 71例未手术的肺癌患者,男52例,女19例,中位年龄63岁,KPS评分≥80.三维适形放疗前、后1、3个月检查患者肺功能,并观察其放射性肺炎的发生及程度,同时在DVH中得出V20、V30、MLD值.结果 所有患者均完成放疗,剂量为66～70 Gy.放射性肺炎发生率为30%,2、3级以上为7%.V20、V30、MLD平均值越大,放射性肺炎程度越高.V20、V30及MLD与CLCO疗前和疗后1、3个月变化及疗后1个月和疗后3个月变化均有相关关系.结论 放疗前后肺功能变化、DVH参数和放射性肺炎程度间存在一定相关关系.放疗后1个月与放疗前CLCO数值变化能更好地预测放射性肺炎发生几率;V20、V30、MLD除了与放射性肺炎发生程度相关外,也与放疗前后CLCO、FEV1的变化有关.
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