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Late course accelerated hyperfractionation radiotherapy for nasopharyngeal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1004-4221.2006.06.002
- Key Word:
- 鼻咽肿瘤/放射疗法;放射剂量分次;预后
Abstract： 目的 研究鼻咽癌后程加速超分割放疗对鼻咽局部控制、生存的影响和并发症状况.方法 全组178例鼻咽癌患者于1995年12月至1998年4月行首次单纯放疗,鼻咽原发灶采用60Coγ线或6 MV X线外照射,其中前4周采用超分割1.2 Gy/次,2次/d,5d/周,间隔≥6 h,剂量为48Gy分40次;后2周采用加速超分割1.5 Gy/次,2次/d,间隔≥6 h,5d/周,剂量为30 Gy分20次,全疗程的总剂量为78Gy分60次6周完成.结果 急性黏膜反应中鼻咽黏膜反应0级仅2例,1级43例,2级78例,3级52例,4级3例.鼻咽5年局部控制率为87.7%,颈部5年局部控制率为85.7%.5年生存率为67.9%.5年远处转移率为26.1%,颅神经损伤占9.0%.结论 该方法患者能耐受,5年局部控制率、生存率比常规分割和超分割有所提高,颅神经等晚期放射性损伤未见明显增加.
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