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Postoperative stereotactic radiotherapy supplementing conventional irradiation in the treatment of 143 patients with brain glioma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1004-4221.2006.05.006
- Key Word:
- 脑肿瘤/放射疗法;立体定向;预后
Abstract： 目的 采用立体定向放疗与常规放疗结合治疗胶质瘤,分析其疗效并探讨其影响预后的因素.方法 对143例脑胶质瘤患者采用立体定向放疗与常规放疗相结合方法.立体定向放疗针对GTV追加剂量,5～7 Gy/次,共5～7次.常规放疗主要针对亚临床病变,一般剂量为50Gy.寿命表法统计生存率.结果 全组患者治疗3～6个月后KPS评分为81±9,与术前的71±9比较有明显改善(t=5.98,P＜0.01).CR 39例(27.3%),PR 70例(49.0%),NC 25例(17.5%),PD 9例(6.3%),有效率为76%.1、3、5年生存率分别为56.6%、36.0%和21.7%.预后因素分析结果显示低分级胶质瘤的患者预后好,而年龄、肿瘤部位、治疗剂量等因素与预后无关.结论 立体定向放疗加常规放疗治疗胶质瘤既发挥了放射物理剂量分布的优点,又符合放射生物学原则,较以往治疗提高了患者的生存机会.
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