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Evaluation of late course accelerated hyperfractionated radiotherapy plus concurrent chemotherapy for esophageal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1004-4221.2006.02.005
- Key Word:
- 食管肿瘤/放射疗法;食管肿瘤/化学疗法;放射剂量分次;预后
Abstract： 目的评价后程加速超分割放疗协同化疗食管癌的疗效和副反应.方法对173例食管鳞癌患者进行前瞻随机分组研究,其中后程加速超分割放疗(LCAHR)组89例,后程加速超分割放疗协同化疗(LCAHR+C)组94例.LCAFR组前2/3疗程常规分割放疗至40Gy(1.8～2.0 Gy/次,1次/d,5d/周),后1/3疗程缩野后改用后程加速超分割(1.5 Gy/次,2次/d,5d/周),全程总剂量60～70Gy,34～42分次,37～42d完成.LCAFR+C组在上述放疗的同时加用化疗,从放疗第1天给予LFP方案:顺铂(PDD)20mg/d,亚叶酸钙(CF)100mg/d,氟尿嘧啶(5-Fu)500mg/d,均连续静脉滴注5 d,28d为1个周期,共4个周期.结果LCAHR组和LCAHR+C组近期总有效率分别为85%和95%(χ2=4.45,P=0.035);1、2、3年局部控制率分别为73%、55%、49%和83%、73%、65%(χ2=5.32,P=0.021);1、2、3年生存率分别为74%、53%、41%和84%、65%、52%(χ2=2.85,P=0.091).LCAHR+C组白细胞减少和消化道反应均明显高于LCAHR组(χ2=7.85、15.06;P=0.005、0.000).结论后程加速超分割放疗协同化疗可提高近期疗效和3年局部控制率,可作为食管癌较有效的治疗手段,但白细胞减少和胃肠反应毒副反应增加.
- [1]陈俊强,陈明强,李云英,等.化疗并后程加速超分割放疗中晚期食管癌[J].2003,(5).
- [2]施学辉,姚伟强.加速超分割放射治疗的理论与实践[J].1998,(3).
- [3]赵快乐,汪洋,施学辉.食管癌后程加速超分割放射治疗的临床分析[J].2001,(1).
- [4]高献书,杨香然,乔学英,等.食管癌后程加速超分割放射合并顺铂治疗的临床研究[J].2002,(2).
- [5]李晓敏,王玉,戴建平,等.食管癌后程加速超分割放射治疗协同化疗的临床研究[J].2003,(1).
- [6]韩春,万钧,周道安,等.100例食管癌后程加速放疗的研究[J].1997,(1).
- [7]G D, Weinstein,T A, Rich,C R, Shumate,etc.Preoperative infusional chemoradiation and surgery with or without an electron beam intraoperative boost for advanced primary rectal cancer.[J].1995,32.
- [8]E A, Poplin,J, Jacobson,A, Herskovic,etc.Evaluation of multimodality treatment of locoregional esophageal carcinoma by Southwest Oncology Group 9060.[J].1996,78(9).
- [9]S G, Taylor,A K, Murthy,K L, Griem,etc.Concomitant cisplatin/5-FU infusion and radiotherapy in advanced head and neck cancer: 8-year analysis of results.[J].1997,19(8).
- [10]Mizowaki T,Matsusue S,Murakami M,etc.Comparison between chemoradiation protocol intended for organ preservation and conventional surgery for clinical T1-T2 esophageal carcinoma.[J].1999,45(2).
- [11]施学辉,吴根娣,刘新伟,等.后程加速超分割放射治疗食管癌的长期疗效[J].1997,(1).
- [12]刘泰福.现代放射肿瘤学[M].2001.