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Nasopharyngeal carcinoma treated with facial cervical portal and late-course hyperfractionation radiotherapy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1004-4221.2006.02.003
- Key Word:
- 鼻咽肿瘤/放射疗法;放射剂量分次;预后
Abstract： 目的观察后程超分割治疗鼻咽癌的疗效及毒副反应.方法93例鼻咽癌患者被随机分为后程超分割治疗组(后超组47例)和常规分割对照组(常规组46例).均先行面颈联合野常规分割对穿照射DT36Gy,20分次,4周,后超组缩野改用后程超分割照射,1.15～1.20Gy/次,2次/d,两次间隔时间6～8 h,5d/周,鼻咽病灶总DT74.8～76.7Gy,54分次,7.5周完成.对照组缩野后常规照射2.0Gy/次,1次/d,鼻咽灶总DT69～72Gy,37～38分次,7.5周完成.颈部均为常规照射.结果后超组和常规组鼻咽部肿瘤消退率分别为100%、96%(χ2=2.10,P＞0.05);1、3、5年肿瘤局部控制率分别为100%、98%、86%和100%、86%、54%(χ2=10.90,P＜0.01);1、3、5年生存率分别为100%、94%、85%和98%、84%、63%(χ2=8.70,P＜0.01).两组放疗口腔黏膜反应无差别(χ2=1.00,P=0.800).后超组复发率低于常规组(11%:30%;χ2=5.60,P＜0.05),而转移率无差别(12.8%:28.3%;χ2=3.40,P＞0.05).结论鼻咽癌后程超分割的局部控制率及长期生存率明显高于常规组,而急性毒性反应及复发转移无明显差别.
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