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Impact of amenia before radiotherapy on the prognosis of nasopharyngeal carcinoma patients
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1004-4221.2006.02.001
- Key Word:
- 鼻咽肿瘤/放射疗法;贫血;预后
Abstract： 目的探讨放疗前贫血对鼻咽癌患者预后的影响.方法回顾性分析的829例鼻咽低分化鳞癌患者中,放疗前贫血者252例.其中轻度贫血者190例,中重度贫血者62例.卡氏评分＞80、≤80和无评价的分别占49.8%、32.4%和17.7%.按1992年福州分期中Ⅲ期和Ⅳ期占74.6%.采用6 MV X线放疗,先面颈大野DT36Gy,后改小面颈野避开脊髓加量至DT50Gy,颈后野电子线补至DT50Gy.原发灶和阳性淋巴结区DT70Gy,预防区DT50～60Gy.残存灶用后装、X刀等技术补量或观察.分析贫血对患者预后的影响以及与其他临床因素的相关性.结果全组患者5、10年总生存率(OS)及无进展生存率(PFS)分别为75.4%、67.1%及62.9%、56.4%.放疗前贫血患者、正常患者的5年OS及PFS分别为67.8%、78.4%及55.0%、66.1%(P＜0.05).贫血与分期及患者一般情况显著相关,与局部控制率无相关性,但与远处转移率显著相关.结论放疗前贫血可显著降低鼻咽癌患者生存率,应纠正患者贫血以提高患者生存质量并进一步研究纠正贫血是否可提高生存率.
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