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Prospective randomized clinical trial of non-small cell lung cancer for intraoperative radiotherapy
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1004-4221.2006.01.004
- Key Word:
- 肺肿瘤/外科学;肺肿瘤/放射疗法;放射疗法,手术中;预后
Abstract： 目的前瞻性分析手术+术后放疗(A组)和手术+术中放疗+术后放疗(B组)非小细胞肺癌的远期疗效.方法154例随机分为两组,每组各77例.其中鳞癌134例,腺癌17例,混合癌3例.临床分期Ⅰ、Ⅱ、Ⅲ期分别为17、76、61例.B组术中照射剂量15～25 Gy ,电子线能量9～20MeV.术后照射采用X线照射,剂量均为40～60 Gy.结果 A和B组肿瘤局部控制率为49%和62%(P＜0.05);3、5、7年生存率分别为40%和44%、27%和29%、5%和7%(P＞0.05).16例死于放射并发症,其中A组2例,B组14例.结论术中放疗+术后放疗能提高肿瘤局部控制率,降低复发率,但不能提高远期生存率.
- [1]曹卡加,黄惠英,练小荷,等.术后放射治疗对非小细胞肺癌疗效的影响[J].2003,(9).
- [2]张灿斌,徐中一,张克.Ⅰ期细支气管肺泡癌和腺癌的临床对比分析[J].2004,(1).
- [3]Jonathan C. Nesbitt,Joe B. Putnam Jr,Garrett L. Walsh,etc.Survival in early-stage non-small cell lung cancer[J].1995,60(2).
- [4]Jauffret B,Levasseur P,Magdeleinat P,etc.Completion pneumonectomy: experience in eighty patients.[J].1999,117(6).
- [5]Thomas A. d'Amato,Michael Galloway,Gary Szydlowski,etc.Intraoperative Brachytherapy Following Thoracoscopic Wedge Resection of Stage I Lung Cancer[J].1998,114(4).
- [6]W Roy, Smythe.Treatment of stage I non-small cell lung carcinoma.[J].2003,123(1 Suppl).
- [7]Timens W,Mehta DM,de Boer-WJ,etc.The short and long term effects of intraoperative electron beam radiotherapy (IORT) on thoracic organs after pneumonectomy an experimental study in the canine model.[J].1999,45(2).
- [8]主编钱秋海, 丛华，全国芳.肺癌[M].2003.
- [9]D W, Zeng,Q S, Chang,Y E, Sun.IORT for non-small-cell lung cancer: preliminary report of 33 cases.[J].1997,31.