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Clinical value of nm23-H1 and survivin protein expression in nasopharyngeal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1004-4221.2005.05.002
- Key Word:
- 鼻咽肿瘤;活组织检查;基因蛋白质类;预测
Abstract： 目的探讨nm23-H1和survivin基因蛋白表达与鼻咽癌(NPC)预后的相关性.方法对115例NPC放疗前活检标本,应用免疫组织化学技术检测nm23-H1和surivin基因蛋白在NPC组织中的表达情况,并分析两基因的表达与NPC分期、放疗敏感性、生存率、转移及复发之间的关系.结果NPC组织中nm23-H1和survivin蛋白阳性表达率分别为47.8%和68.7%.NPC分期、淋巴结转移、生存率及远处转移与nm23-H1蛋白低表达有密切关系,而survivin的高表达则与鼻咽癌的颈淋巴结转移、放疗敏感性、生存率及复发有密切关系.nm23-H1蛋白表达与survivin表达呈负相关(P＜0.05).结论nm23-H1蛋白低表达和survivin高表达对判断病变进展、预测放疗敏感性、生存率及转移和复发有重要参考价值.
- [1]王卫东,陈正堂.凋亡抑制因子Survivin的研究进展[J].2001,(4).
- [2]姜武忠,申良方,涂青松.放射治疗加化疗治疗晚期鼻咽癌的临床研究[J].2002,(12).
- [3]姜武忠,文继舫.nm23基因与肿瘤关系研究进展[J].2003,(13).
- [4]闵华庆,洪明晃,马骏,等.鼻咽癌新分期的研究[J].1992,(4).
- [5]郑天荣,谢佐福,林贤东,等.NM23蛋白在人鼻咽癌中的表达[J].1997,(2).
- [6].全国鼻咽癌会议纪要[J].1992,(4).
- [7]Jennifer Tran,Janusz Rak,Capucine Sheehan,etc.Marked Induction of the IAP Family Antiapoptotic Proteins Survivin and XIAP by VEGF in Vascular Endothelial Cells[J].1999,264(3).
- [8]Li, Fengzhi,Ambrosini, Grazia.Control of apoptosis and mitotic spindle checkpoint by survivin.[J].1998,396(6711).
- [9]Mirza Asra,McGuirk Marnie,Hockenberry TishN,etc.Human survivin is negatively regulated by wild-type p53 and participates in p53-dependent apoptotic pathway.[J].2002,21(17).
- [10]P S, Steeg,G, Bevilacqua,L, Kopper,etc.Evidence for a novel gene associated with low tumor metastatic potential.[J].1988,80.
- [11]李岩松,郑朝晖,黄应桂.人大肠癌组织中nm23-H1表达及其与转移的关系[J].1998,(4).