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Impact of tumor local factors on radiotherapy in non- small cell lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1004-4221.2005.04.003
- Key Word:
- 癌,非小细胞肺/放射疗法;放射疗法,适形;预后
Abstract： 目的回顾性分析根治性放疗的非小细胞肺癌(NSCLC)病例,探讨肿瘤局部因素对放疗疗效的影响.方法接受根治性放疗并经病理或细胞学证实的Ⅰ～Ⅲb期NSCLC 75例.常规放疗39例,适形放疗36例,总剂量60～70Gy,30～35分次,6～7周完成.由CT扫描测量肿瘤最大直径及体积,对相关指标进行单因素、多因素分析,并用预后指数模型综合评价放疗疗效.结果完全缓解(CR)率33.3%(25/75),有效率(CR+PR)率85.3%(64/75),无变化加病变进展(NC+PD)率14.7%(11/75).中位生存期13.8个月,1.0、1.5年生存率分别为54.7%、27.5%.单因素及多因素分析显示原发肿瘤直径较小、体积较小、T分期较早、总治疗时间较短和放射性肺炎较轻者预后较好.预后指数能够更敏感地预测放疗疗效.结论原发肿瘤直径、肿瘤体积、T分期、总治疗时间、急性放射性肺炎有可能成为放疗NSCLC的独立影响因素,预后指数模型能够显著提高多指标联合的预测价值.
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