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Escalated hyperfractionated accelerated radiotherapy combined with chemotherapy for non-small cell lung cancer: a phase Ⅱ clinical trial
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1004-4221.2005.03.004
- Key Word:
- 癌,非小细胞肺/放射疗法;放射剂量分次;癌,非小细胞肺/化学疗法;预后
Abstract： 目的研究逐步递量加速超分割照射加化疗治疗Ⅲb期非小细胞肺癌的耐受性、副反应和疗效.方法73例中男59例,女14例,中位年龄60岁(33～70岁).放疗方案为2次/d,间隔＞6 h,5d/周.第1、2周,1.2 Gy/次,2次/d;第3、4、5周分别为1.3、1.4、1.5 Gy/次,2次/d.肿瘤灶总剂量为66Gy,50分次,5周完成.化疗为MVP或EP方案.结果73例中12例未完成既定的治疗计划.完成的化疗中位疗程数为4个,完成的放疗中位肿瘤灶剂量为66Gy.急性放射性食管炎发生率为77%,其中3级为15%.急性放射性肺炎发生率为40%,其中3级为8%.73例的中位生存时间为13个月,1、2年生存率分别为51%、10%.完成既定放疗的61例中34例出现局部复发,其中32例在照射野内,2例在野外.1、2年局部控制率分别为71%、34%.1、2年远地转移率分别为57%、84%.结论逐步递量加速超分割照射加化疗能被绝大多数Ⅲb期患者所耐受,局部控制有所改善,由于远地转移使长期生存并无明显提高.
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