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Study on fractionation for early non-small cell lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1004-4221.2005.03.003
- Key Word:
- 癌,非小细胞肺/放射疗法;放射疗法,适形;放射剂量分次;预后
Abstract： 目的比较三维适形大分割加速放疗与常规分割放疗早期非小细胞肺癌的疗效.方法60例Ⅰ、Ⅱ期非小细胞肺癌(NSCLC)患者随机均分为两组,一组行大分割加速放疗,4 Gy/次,5次/周,总剂量48Gy,2～3周完成;另一组行常规分割放疗,2Gy/次,5次/周,总剂量66Gy,6～7周完成.其中Ⅰ期患者行单纯放疗,Ⅱ期患者行放化疗,化疗采用NP方案,共4个疗程.结果大分割加速放疗组1、2、3年总生存率和无病生存率分别为80%和65%、60%和50%、43%和33%,常规分割放疗组分别为60%和45%、33%和23%、23%和10%;远地转移率分别为13%、37%;局部复发率分别为23%、50%;放射性肺炎和放射性食管炎及骨髓抑制发生率相当,分别为50%和53%及57%、40%和50%及47%.结论三维适形大分割加速放疗早期NSCLC的效果优于常规分割放疗,毒副反应可以耐受.
- [1]李万龙,于金明,刘国华,等.非小细胞肺癌影像学与病理学靶区关系的研究[J].2003,(6).
- [2]主编沈瑜, 糜福顺.肿瘤放射生物学[M].2002.
- [3]Basrur V,Balogh J,Ung YC,etc.Accelerated hypofractionation for early-stage non-small-cell lung cancer.[J].2002,54(4).
- [4]J M, Robertson,R K, Ten Haken,M B, Hazuka,etc.Dose escalation for non-small cell lung cancer using conformal radiation therapy.[J].1997,37.
- [5]B J, Slotman,I E, Antonisse,K H, Njo.Limited field irradiation in early stage (T1-2N0) non-small cell lung cancer.[J].1996,41.
- [6]Paliwal B,Mehta M,Scrimger R,etc.A new approach to dose escalation in non-small-cell lung cancer.[J].2001,49(1).
- [7]Hazuka MB,Ten Haken-RK,Martel MK,etc.Estimation of tumor control probability model parameters from 3-D dose distributions of non-small cell lung cancer patients.[J].1999,24(1).
- [8]L, Malissard,T D, Nguyen,G M, Jung,etc.Localized adenocarcinoma of the lung: a retrospective study of 186 non-metastatic patients from the French Federation of Cancer Institutes--the Radiotherapy Cooperative Group.[J].1991,21.
- [9]Bradley JD,Lockett MA,Perez CA,etc.Elective nodal failures are uncommon in medically inoperable patients with Stage I non-small-cell lung carcinoma treated with limited radiotherapy fields.[J].2003,56(2).