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Preliminary results of dynamic perfusion computed tomography in the radio-sensitivity prediction for nasophargeal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 3
- DOI:
- 10.3760/j.issn:1004-4221.2004.03.005
- Key Word:
- 鼻咽肿瘤;体层摄影术,X线计算机;辐射敏感性;预测
Abstract： 目的初步探讨螺旋CT灌注成像扫描在预测鼻咽癌放射敏感性的应用价值.方法对经病理证实的52例鼻咽癌行治疗前螺旋CT动态扫描,通过时间-密度曲线计算鼻咽部肿瘤和未受侵犯的翼外肌的灌注数据.患者均接受常规放射治疗,外照射至DT50Gy时行鼻咽部CT复查,分别测量治疗前和外照射DT50 Gy时肿瘤最大截面积.分析各灌注参数与肿瘤消退率(RSO-50)关系.结果全组病例鼻咽肿瘤的血流量(BF)、血容量(BV)、平均通过时间(MTT)和表面通透性(PS)的平均值分别为401.8ml·min-1·100 g-1、9.0ml/100g、3.1s和66.0ml·min-1·100g-1.Pearson相关分析结果显示各灌注参数与RSO-50均无明显直线相关关系.将RSO-50≤0.75定为放射治疗低敏感组,＞0.75为高敏感组.肿瘤与肌肉组织的BF、BV比值结果显示高敏感组rBF平均值为16.1,低敏感组为9.7(t=1.92,P=0.06);高敏感组rBV平均值为3.0,低敏感组为2.3(t=1.84,P=0.07).结论螺旋CT动态灌注扫描预测鼻咽癌放射敏感性需要更进一步的研究.
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