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Chemoradiotherapy for youngster lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1004-4221.2004.02.003
- Key Word:
- 肺肿瘤/化学疗法;肺肿瘤/放射疗法;病理学;预后
Abstract： 目的探讨化疗+放射治疗(化放疗)＜40岁青年人肺癌的临床病理及预后.方法对化放疗的70例肺癌患者(＜40岁,研究组)进行回顾性研究,对照组是82例随机选择同期患者(≥40岁).比较两组临床病理特征和生存期.结果研究组中位年龄36.5岁,对照组62.0岁.与对照组相比,研究组中女性多(P=0.039),中位症状持续时间长(4个月,P＜0.001),误诊率高(70%,P＜0.001)及中位误诊时间长(4个月,P＜0.001),腺癌为主要病理类型(64.3%,P＜0.001),诊断时晚期多(90%,P＜0.001),放射治疗剂量高(Ⅰ～Ⅲb期,中位剂量62 Gy,P=0.048;Ⅳ期,中位剂量56 Gy,P=0.003),同期化放疗和早期放射治疗比例高(77.1%,P＜0.001和55.6%,P=0.023),顺铂剂量高(90 mg/m2,P＜O.001)以及化疗周期多(6个周期,P＜0.001);两组在体重减轻、KPS、肿瘤家族史及吸烟史方面无差异.两个组总的中位生存时间及生存率比较差异无显著性意义(X2=2.88,P=0.090).结论化放疗的青年人肺癌临床病理特征明显不同于≥40岁人的肺癌,但生存情况一致.将青年人肺癌定义为"青年型肺癌"有一定临床实际意义.
- [1]William Bourke,David Milstein,Raffaele Giura,etc.Lung Cancer in Young Adults[J].1992,102(6).
- [2]Shirish M. Gadgeel,Sakkaraiappan Ramalingam,Glenn Cummings,etc.Lung Cancer in Patients <50 Years of Age: The Experience of an Academic Multidisciplinary Program[J].1999,115(5).
- [3]Liu B.-Q.,Peto R.,Chen Z.-M.,etc.Emerging tobacco hazards in China: 1.\u00a0Retrospective proportional mortality study of one million deaths[J].1998.
- [4]M, Kreuzer,L, Kreienbrock,M, Gerken,etc.Risk factors for lung cancer in young adults.[J].1998,147.
- [5]T, Shimono,T, Hayashi,M, Kimura,etc.Surgical treatment of primary lung cancer in patients less than 40 years of age.[J].1994,12.
- [6]Choi N,Baumann M,Flentjie M,etc.Predictive factors in radiotherapy for non-small cell lung cancer: present status.[J].2001,31(1).
- [7]Leon S. Green,Teresa I. Fortoul,Guadalupe Ponciano,etc.Bronchogenic Cancer in Patients Under 40 Years Old: The Experience of a Latin American Country[J].1993,104(5).
- [8]Bourdeau HA,Tirpak DL,Luketich JD,etc.Sex-specific expression of gastrin-releasing peptide receptor: relationship to smoking history and risk of lung cancer.[J].2000,92(1).
- [9]Herbst RS,Skarin AT,Sugarbaker D,etc.Lung cancer in patients under age 40.[J].2001,32(3).
- [10]Kitajima M,Yoshino I,Ichinose Y,etc.Lung cancer in patients younger than 40 years of age.[J].2001,77(3).
- [11]E A, Zang,E L, Wynder.Differences in lung cancer risk between men and women: examination of the evidence.[J].1996,88.