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Relationship between primary tumor volume and radiotherapeufic outcome in nasopharyngeal carcinoma

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF RADIATION ONCOLOGY

Issue:: 2

DOI:: 10.3760/j.issn:1004-4221.2004.02.001

Key Word:: 鼻咽肿瘤;体层摄影术,X线计算机;放射疗法

Abstract：目的分析鼻咽癌原发肿瘤容积与放射治疗疗效的关系.方法无远地转移的154例初治鼻咽癌患者行超分割后程加速放射治疗,原发灶总剂量为78 Gy,60分次,6周完成.在治疗前CT资料上勾画鼻咽部肿瘤,采用求和方法算得肿瘤容积.结果不同T分期中肿瘤容积变化范围很大,T1、T2、T3、T4期平均肿瘤容积(范围)分别为18.9(0.55～59.33)、25.8(2.22～80.64)、39.3(13.97～87.97)、59.7(26.18～115.00)cm3.单因素分析显示原发肿瘤容积＞60cm3的患者5年鼻咽部控制率、无瘤生存率和无远地转移率均明显降低.多因素分析中,原发肿瘤容积是影响局部控制的一个独立预后因子,但该因素在影响无瘤生存率和无远地转移生存率的因素中未达统计学意义.结论鼻咽癌不同T分期中存在着很大的肿瘤容积重叠范围,原发肿瘤容积是影响放射治疗疗效的一个重要因素.

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