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Fractionated stereotactic radiotherapy for locally residual or recurrent nasopharyngeal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1004-4221.2004.01.002
- Key Word:
- 鼻咽肿瘤;肿瘤残留,局部;肿瘤复发,局部;立体定向放射疗法
Abstract： 目的评价分次立体定向放射治疗(FSRT)对局部残留和复发鼻咽癌的初步疗效.方法应用FSRT对30例局部残留(11例)或复发(19例)鼻咽癌患者分2个组进行治疗,其残留组和复发组中位处方剂量分别为18 Gy和48 Gy,中位分次量分别为6 Gy和8Gy,每周2次.结果可评价例数共29例,FSRT治疗后3个月残留组的CR和PR各为6/11和3/11,复发组各为8/18和8/18.全组病例随诊3.4～37.9个月(中位值15个月),残留组1和2年总生存率、无瘤生存率、无局部复发生存率和无远地转移生存率分别为77.8%和66.7%、56.8%和56.8%、88.9%和88.9%、75.0%和75.0%,复发组相应为69.8%和59.8%、53.4%和44.5%、76.6%和63.8%、70.5%和58.7%.残留组和复发组生存患者卡氏评分≥90者分别占8/8和11/13.结论FSRT对局部残留或复发鼻咽癌有较好的局部控制效果和较高的安全性,区域和远地转移是治疗失败的主要原因.
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