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Significance of different preoperative radiotherapy doses in combined therapy for hypopharyngeal squamous cell carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1004-4221.2004.01.001
- Key Word:
- 下咽肿瘤/放射疗法;放射疗法,术前;下咽肿瘤/外科学;预后
Abstract： 目的探讨下咽鳞癌不同术前放射治疗剂量对综合治疗的影响.方法回顾性分析201例(男181例,女20例;年龄32～75岁)经术前放射治疗+手术综合治疗(R+S)的下咽鳞癌(1997年UICC分期Ⅰ期6例,Ⅱ期14例,Ⅲ期47例,Ⅳ期134例),其中梨状窝173例,咽后壁19例,环后9例.124例术前放射治疗40Gy,77例术前放射治疗50Gy;放射治疗后2周左右给予手术治疗.结果术前放射治疗40Gy组5年生存率为39.7%,50Gy组为55.4%(P＜0.05).术前放射治疗40Gy组放射治疗相关性术后并发症发生率为26.6%,50Gy组为15.6%(P＜0.05).术前放射治疗40Gy组喉功能保留率为38.7%,50Gy组为42.9%(P＞0.05).术前放射治疗40Gy组区域复发率为28.2%,50Gy组为29.9%(P＞0.05).结论术前放射治疗50Gy较40Gy能提高下咽鳞癌的远期生存率,且不增加放射治疗引起的术后并发症,并有望增加喉功能的保留率.
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