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Combined whole brain and radiotherapy with teniposide for brain metastasis of lung cancer : phase I clinical study
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1004-4221.2003.04.004
- Key Word:
- 转移肿瘤,脑/放射疗法;转移肿瘤,脑/化学疗法;临床研究
Abstract： 目的通过全脑照射加Vm-26综合治疗肺癌脑转移,观察其毒性、耐受剂量及临床可行性.方法 16例患者为研究对象,全脑照射总剂量DT40 Gy,DT2 Gy/次,5次/周,20次共4周.Vm-26分50、75、100 mg/m2 3个剂量级,每剂量组至少3例,如无明显毒副反应进入下一剂量组,直至找到最大耐受量(MTD),1次/周,共4次. 结果主要毒副反应为骨髓抑制.第2个剂量级中有2例出现3、4级骨髓抑制,MTD为75 mg/m2.结论肺癌脑转移全脑照射加Vm-26综合治疗具有临床可行性,最大耐受剂量75 mg/m2,推荐Ⅱ期临床剂量为50 mg/m2.
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