You Position: Home > Paper
Three-dimensional conformal hypofractionated high-dose radiotherapy combined with chemotherapy for non-small-cell lung cancer
( views:240, downloads:25 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1004-4221.2003.04.002
- Key Word:
- 肺肿瘤/放射疗法;放射疗法,适形;预后
Abstract： 目的探讨三维适形大分割照射结合化疗治疗非小细胞肺癌(NSCLC)的疗效.方法 43例NSCLC中鳞癌30例、腺癌10例、腺鳞癌3例.全部患者放射治疗前均用健择(1000 mg/m2第1、8天)和顺铂(30 mg/m2第1～3天)化疗3个周期,21 d为一疗程.放射治疗采取肿瘤直径≤7 cm者5～7个适形野,＞7 cm者3～4个适形野;48～60 Gy,8～10分次,21～24 d完成.锁骨上淋巴结转移的患者用12 MeV的电子线常规分割放射治疗,剂量66～70 Gy,7周完成.结果 43例近期疗效中, 12例完全缓解(CR),22例部分缓解(PR),4例稳定(NC),5例进展(PD),肿瘤总有效(CR+PR)率为 79.1%(34/43).1、2、3年生存率分别为75.2%、53.2%、35.4%.结论三维适形大分割照射结合化疗治疗NSCLC有较好的疗效,更远期疗效尚待进一步观察.
- [1]李代蓉,李志平,郝德治.肺癌的适形放疗研究进展[J].2002,(2).
- [2]孙燕主编.内科肿瘤学[M].2001.
- [3]Halle J,Socinski M,Morris D,etc.High-dose conformal radiotherapy for treatment of stage IIIA/IIIB non-small-cell lung cancer: technical issues and results of a phase I/II trial.[J].2002,54(2).
- [4]Diana Francesco,Facciolo Franco,Martelli Olga,etc.A 3-week schedule of gemcitabine plus cisplatin as induction chemotherapy for Stage III non-small cell lung cancer.[J].2002,35(3).
- [5]蒋国梁.束流调强的适形立体放射治疗[J].1997,(2).
- [6]Kortsik C,Elmer A,Albrecht P.Gemcitabine and carboplatin in patients with locally advanced or metastatic non-small cell lung cancer: a prospective phase II study.[J].2003,40(1).
- [7]Paliwal B,Mehta M,Scrimger R,etc.A new approach to dose escalation in non-small-cell lung cancer.[J].2001,49(1).
- [8]Orlando M,Silva C,Vilanova M,etc.Neoadjuvant chemotherapy with gemcitabine and cisplatin in stage IIIA/B non-small cell lung cancer.[J].2002,20(4).
- [9]J D, Cox,N, Azarnia,R W, Byhardt,etc.N2 (clinical) non-small cell carcinoma of the lung: prospective trials of radiation therapy with total doses 60 Gy by the Radiation Therapy Oncology Group.[J].1991,20.
- [10]Nagata Y,Negoro Y,Aoki T,etc.Clinical outcomes of 3D conformal hypofractionated single high-dose radiotherapy for one or two lung tumors using a stereotactic body frame.[J].2002,52(4).
- [11]Choi N,Baumann M,Flentjie M,etc.Predictive factors in radiotherapy for non-small cell lung cancer: present status.[J].2001,31(1).
- [12]J D, Cox,J, Stetz,T F, Pajak.Toxicity criteria of the Radiation Therapy Oncology Group (RTOG) and the European Organization for Research and Treatment of Cancer (EORTC)[J].1995,31.