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Combined treatment of brain metastasis in non-small cell lung cancer
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1004-4221.2003.01.005
- Key Word:
- 癌,非小细胞肺;癌,脑转移;综合疗法;预后
Abstract： 目的通过回顾性分析探讨影响非小细胞肺癌脑转移治疗效果的预后因素.方法对133例非小细胞肺癌脑转移患者进行以全脑放射治疗为主结合其他方法的治疗.脑转移症状缓解定义为脑部放射治疗结束后1个月,50%以上的症状和体征消失.将脑转移时原发灶控制与否、脑外转移灶、单发或多发脑转移、化疗周期等因素进行多因素分析.结果所有患者经放射治疗后脑转移灶症状缓解率达88%,缓解期为1.5～55.0个月,中位缓解期为6个月;全脑放射治疗后CT或MRI显示脑转移灶局部控制率为83%;全组中位生存期为6个月,1、2年生存率分别为24.5%和7.8%.经多因素分析显示生存率与多发脑转移、原发灶未控呈负相关,而与化疗3周期以上呈正相关.结论影响非小细胞肺癌脑转移的主要因素是脑转移时原发灶控制与否、多发或单发脑转移、化疗周期数.对于单发脑转移、脑转移时原发灶控制以及身体条件能够耐受3周期以上化疗的患者,应采取积极的治疗.
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