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Combined therapy for 442 patients with limited small cell lung cancers
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1004-4221.2003.01.004
- Key Word:
- 癌,小细胞肺/化学疗法;癌,小细胞肺/放射疗法;综合疗法;预后
Abstract： 目的通过局限期小细胞肺癌先化疗后放射治疗(先化后放组)和化疗+放射治疗+化疗(化放化组)2个组的疗效比较,分析影响预后因素.方法局限期小细胞肺癌442例随机分为先化后放组(228例)和化放化组(214例).先化后放组为化疗4周期后放射治疗,化放化组为化疗2周期后放射治疗1个疗程再化疗2周期.放射治疗技术和剂量两组相同,大多数病例总量DT50～70 Gy,5～7周,照射野包括原发灶、肺门、纵隔及双锁骨上淋巴引流区.化疗方案有COMP、COMVP和CE-CAP.结果全组总有效率为78.1%,局部复发率分别为34.6%和35.0%.2个组远地转移率分别为57.5%和57.9%.结论 2个组的近期疗效、长期生存、局部复发率和远地转移率均无统计学差异.
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