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Prognostic factors of early glottic cancer treated with definitive radiotherapy

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Author:: No author available

Journal Title:: CHINESE JOURNAL OF RADIATION ONCOLOGY

Issue:: 2

DOI:: 10.3760/j.issn:1004-4221.2002.02.003

Key Word:: 喉肿瘤/放射疗法;预后因素

Abstract：目的分析单纯放射治疗早期声门型喉癌(T1N0M0)的预后因素.方法 1958年8月至1994年12月,肿瘤医院共收治行单纯放射治疗的T1N0M0声门型喉鳞癌238例,其中男性220例,女性18例.用6、8MV X射线或60Co予平行对穿野放射治疗,中位放射总剂量为68Gy,中位治疗时间52d,中位放射野大小22.5cm2.用Kaplan-Meier法计算生存率和局部控制率,Logrank法做差异检验,Cox回归法统计影响局部控制率(LC)和总生存率(OS)的预后因素.结果中位随访时间127个月(4～410个月).5、10年总生存率分别为84.0%和74.9%.5年局部控制率为82.2%.44例在随访过程中出现局部复发(41例为原发部位复发,2例为颈部淋巴结复发,1例因失访复发部位不详),23例出现第二原发肿瘤.对LC不利的预后影响因素为局部大肿块、前联合受侵和治疗过程中血红蛋白下降.结论单纯放射治疗T1N0M0声门型喉癌可得到很好的局部控制率,但局部大肿块、前联合受侵和血红蛋白在治疗过程中下降是对局部控制不利的预后因素.

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