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Combined hyperfractionated radiotherapy and concurrent chemotherapy for stage Ⅲ-Ⅳ nasopharyngeal carcinoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1004-4221.2002.02.002
- Key Word:
- 鼻咽肿瘤/放射疗法;鼻咽肿瘤/化学疗法;预后
Abstract： 目的比较超分割加同期化疗与单纯超分割放射治疗Ⅲ～Ⅳ期鼻咽癌的生存率和局部控制率.方法 150例鼻咽癌患者随机分入超分割加同期化疗组(研究组)和单纯超分割放射治疗组(对照组).放射治疗方式2个组相同,1.2Gy/次,2次/d.研究组在放射治疗前、中加用化疗,放射、化疗同期进行.结果 5年总生存率为57.3%,5年无瘤生存率和无远地转移生存率均为55.9%.研究组和对照组5年生存率分别为64.0% 和50.7%,(χ2=4.26,P=0.037).研究组有1例鼻咽部复发而对照组有5例鼻咽部复发,5年局部控制率分别为98.7%和93.4%.研究组的急性黏膜反应高于对照组,但能耐受,无严重并发症发生. 结论超分割放射同期化疗治疗Ⅲ～Ⅳ期鼻咽癌生存率和局部控制率有所提高,且能耐受.化疗对Ⅳ期的生存率影响更大.
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