You Position: Home > Paper
Prospective randonmized study on inductive chemotherapy plus radiotherapy for patients with upper and middle esophageal carcinoma
( views:269, downloads:76 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1004-4221.2002.01.004
- Key Word:
- 食管肿瘤/化学疗法;诱导化疗;食管肿瘤/放射疗法;预后
Abstract： 目的探讨联合诱导化疗提高中上段食管癌放射治疗疗效的方法.方法 162例食管癌患者根据入选标准随机分组,82例进入化疗+放射治疗(化放组),80例进入单纯放射治疗(单放组).化疗方案:氟尿嘧500mg/m2·d-1,5d;顺铂60mg/m2,第1天;平阳霉素8mg/次,隔日1次,3次.化疗结束后3～7d开始放射治疗.放射治疗:60Coγ射线照射,先设前后(2∶1)野DT40～44Gy4.0～4.4周,结束后成角缩野追加DT24～28Gy2.4～2.8周.结果化放组的5、10年生存率分别为22.0%、15.9%,单放组的5、10年生存率分别为13.8%、8.8%,两组间生存率差异有显著性意义(P=0.034).两组的毒副反应相似,患者均能耐受.两组的主要死亡原因是局部复发,但化放组死于远地转移及淋巴结转移的病例与单放组比较差异无显著性意义(χ2=3.47,P》0.05).结论以氟尿嘧啶、顺铂及平阳霉素联合诱导化疗加放射治疗中上段食管癌可以提高疗效.虽毒副反应有所增加,但所有患者均可耐受.
- [1]Y, Zhu,X Q, Jiang,J, Van Dyk.Portal dosimetry using a liquid ion chamber matrix: dose response studies.[J].1995,22(7).
- [2]R, Boellaard,M, van Herk,B J, Mijnheer.The dose response relationship of a liquid-filled electronic portal imaging device.[J].1996,23(9).
- [3]P M, Evans,V N, Hansen,W P, Mayles,etc.Design of compensators for breast radiotherapy using electronic portal imaging.[J].1995,37.
- [4]M, van Herk,H, Meertens.A matrix ionisation chamber imaging device for on-line patient setup verification during radiotherapy.[J].1988,11(4).
- [5]胡逸民.肿瘤放射物理学[M].1999.
- [6]H, Meertens,M, van Herk,J, Bijhold,etc.First clinical experience with a newly developed electronic portal imaging device.[J].1990,18.
- [7]F F, Yin,M C, Schell,P, Rubin.Input/output characteristics of a matrix ion-chamber electronic portal imaging device.[J].1994,21(9).
- [8]Donovan EM,Evans PM,Garton A,etc.Radiological thickness measurement using a liquid ionization chamber electronic portal imaging device.[J].1999,44(6).
- [9]van Herk M..Physical aspects of a liquid-filled ionization chamber with pulsed polarizing voltage[J].1991,18(4).
- [10]Chang J,Ling CC,Chui CS,etc.Relative profile and dose verification of intensity-modulated radiation therapy.[J].2000,47(1).
- [11]Quint S,Heijmen BJ,Pasma KL,etc.Transit dosimetry with an electronic portal imaging device (EPID) for 115 prostate cancer patients.[J].1999,45(5).
- [12]Dirkx ML,Heijmen BJ,Pasma KL,etc.Dosimetric verification of intensity modulated beams produced with dynamic multileaf collimation using an electronic portal imaging device.[J].1999,26(11).