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Delayed radiation injury of brain stem after radiotherapy in nasopharyngeal
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1004-4221.2002.01.002
- Key Word:
- 鼻咽肿瘤/放射疗法;脑干/放射损伤;磁共振成像
Abstract： 目的探讨鼻咽癌放射治疗后迟发性脑干损伤的临床特点、MRI表现、诊断、治疗、预后及相关因素.方法对24例鼻咽癌放射治疗后脑干损伤患者进行回顾性分析,男14例,女10例.潜伏期为6～38个月,中位潜伏期18个月.病灶部位:脑桥10例,中脑+脑桥4例,脑桥+延髓5例,延髓2例,中脑+脑桥+延髓3例.MRI表现为T1WI以低信号为主,T2WI均为高信号.结果 18例早期用地塞米松治疗,12例症状体征有不同程度的改善,6例无效.8例在出现神经症状8～38个月死亡,现生存16例,生存时间为0.5～6.0年.结论放射性脑干损伤潜伏期短,症状重,治疗困难,预后差.建议设野时注意保护脑干,尽量减少脑干照射体积及照射剂量,以减少脑干放射损伤的发生率.
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