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Is prophylactic irradiation of Waldeyer's ring necessary for primary non-Hodgkin's lymphoma in the neck
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIATION ONCOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1004-4221.2001.04.001
- Key Word:
- 非霍奇金淋巴瘤/放射疗法;综合治疗;韦氏环
Abstract： 目的探讨颈淋巴结非霍奇金淋巴瘤(NHL)是否需预防照射韦氏环? 方法对颈淋巴结淋巴瘤,分期检查中特别注意剔除韦氏环、纵隔和腋窝受累者.106例临床局限于颈淋巴结的NHL中,单纯放射治疗17例,放射+化疗89例.化疗方案为CHOP或COMP.预防照射韦氏环者常规用面颈联合野,不照射韦氏环者主要用颈切线野.侵犯一侧颈者(Ⅰ期)90例,侵犯两侧颈者(Ⅱ期)16例.侵犯上中颈且病理为中高度恶性的80例列入分析组.结果分析组做化疗并预防照射韦氏环者5年生存率和5年无瘤生存率(DFS)分别为58.4%、58.8%;做化疗未预防照射者5年生存率和DFS分别为67.4%及63.8%(P值均>0.05).全组预防和未预防照射韦氏环者韦氏环复发率分别为0%(0/43)和1.6%(1/63),分析组中预防和未预防照射韦氏环者韦氏环复发率分别为0%(0/34)和2.2%(1/46).结论颈淋巴结NHL似可不预防照射韦氏环,特别在做化疗+放射综合治疗时更可如此.治疗前须常规做韦氏环特别是鼻咽部活检及CT检查,以排除原发性韦氏环NHL.
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