Diffusion tensor MR imaging in the assessment of cognitive functions in children with periventricular leukomalacia
- Author:
- No author available
- Journal Title:
- Chinese Journal of Radiology
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1005-1201.2012.03.002
- Key Word:
- 脑性瘫痪;磁共振成像,弥散;认知障碍;Cerebral palsy;Diffusion magnetic resonance imaging;Cognition disorders
Abstract： Objective To investigate the values of diffusion tensor MR imaging(DTI)and fiber tractography(FT)in the assessment of cognitive functions in children with periventricular leukomalacia (PVL),to facilitate to understand the mechanism of PVL children's cognitive functions.Methods Forty six children with PVL and 16 age-matched volunters were recruited.Developmental quotient(DQ)of all cases was recorded.According to the DQ scores,patients were divided into 3 groups:mild in 11 patients,moderate in 19,and severe in 16.DTI was performed in all cases and fractional anisotropy(FA)values were be calculated.Non-paired t test was used to compare the FA values of major white matter fibers between patients group and controls group.One-way ANOVA was used to compare the FA values among 4 groups.Results Compared with controls,all 46 patients with PVL showed a significant mean FA reduction in left corticospinal tract(CST)(0.476 ±0.064 vs.0.531 ±0.064),bilateral anterior limb of internal capsula (ICAL)(left 0.357 ±0.050 vs.0.405 ±0.081,right 0.370 ±0.040 vs.0.405 ±0.036),posterior limb of internal capsule(ICPL)(left 0.483 ±0.044 vs.0.546 ±0.091,right 0.485 ±0.046 vs.0.547 ±0.083),arcuate fasciculus(AF)(left 0.367 ± 0.069 vs.0.433 ± 0.097,right 0.363 ± 0.064 vs.0.421 ±0.091),posterior thalamic radiation(PTR)(left 0.390 ± 0.059 vs.0.459 ± 0.067,right 0.382 ± 0.047 vs.0.446 ± 0.064),anterior CG(ACG)(left 0.362 ± 0.056 vs.0.423 ± 0.057,right 0.345 ± 0.056 vs.0.417 ± 0.080),superior longitudinal fasciculus(SLF)(left 0.323 ± 0.050 vs.0.426 ±0.102,right 0.341 ± 0.056 vs.0.416 ± 0.092)and splenium of the corpus callosum(SCC)(0.535 ±0.090 vs.0.606 ±0.060)(t =2.037-3.745,P ＜0.05).The severity of cognitive impairment companied with decrease of the FA values of all fibers.The FA values of bilateral CST,ICAL,ICPL,left AF,bilateral PTR,ACG,SLF and SCC were significantly different among different groups(F =3.021-7.146,P ＜ 0.05).Conclusions The damage widespread of white matter bundles is found in children with PVL DTI and FT can provide details in the assessment of cognitive impairment in children with PVL.
- [1]《中华儿科杂志》编辑委员会,中华医学会儿科学分会神经学组.小儿脑性瘫痪的定义、诊断条件及分型[J].2005,(4).
- [2]谢晟,郭雪梅,崔爱国,等.儿童脑室周围白质软化症的MR扩散张量成像研究[J].2005,(3).
- [3]周雪娟,陈彤,江克文,等.Gesell发育量表对婴幼儿脑瘫康复疗效的评估[J].1999,(5).
- [4]范晓颖,肖江喜,蒋学祥,等.儿童脑室周围白质软化症的MRI与临床对比研究[J].2003,(3).
- [5]Allin M,Jones D,Cuddy M,etc.Diffusion tensor MRI of the corpus callosum and cognitive function in adults born preterm.[J].2009,20(4).
- [6]Counsell SJ,Edwards AD,Chew AT,etc.Specific relations between neurodevelopmental abilities and white matter microstructure in children born preterm.[J].2008,131(Pt.12).
- [7]Wandell B,Dougherty RF,Bammer R,etc.Children's reading performance is correlated with white matter structure measured by diffusion tensor imaging.[J].2005,41(3).
- [8]Katherine L. Narr,Arthur W. Toga,Eileen Luders,etc.Neuroanatomical correlates of intelligence[J].2009,37(2).
- [9]Beaulieu C.The basis of anisotropic water diffusion in the nervous system - a technical review.[J].2002,15(7).
- [10]C. Lepage,S. Karama,R.J. Haier,etc.Positive association between cognitive ability and cortical thickness in a representative US sample of healthy 6 to 18 year-olds[J].2009,37(2).
- [11]Wilke M,Holland SK,Schmithorst VJ,etc.Cognitive functions correlate with white matter architecture in a normal pediatric population: a diffusion tensor MRI study.[J].2005,26(2).
- [12]Milos, Judas,Marko, Rados,Natasa, Jovanov-Milosevic,etc.Structural, immunocytochemical, and mr imaging properties of periventricular crossroads of growing cortical pathways in preterm infants.[J].1900,26.
- [13]G G, Fan,B, Yu,S M, Quan,etc.Potential of diffusion tensor MRI in the assessment of periventricular leukomalacia.[J].2006,61(4).
- [14]Nagae LM,Hoon AH Jr,Stashinko EE.Sensory and motor deficits in children with cerebral palsy born preterm correlate with diffusion tensor imaging abnormalities in thalamocortical pathways.[J].2009,51(9).
- [15]Deary IJ,Bastin ME,Pattie A,etc.White matter integrity and cognition in childhood and old age.[J].2006,66(4).
- [16]Pavlova M,Staudt M,Grodd W,etc.Pyramidal tract damage correlates with motor dysfunction in bilateral periventricular leukomalacia (PVL).[J].2003,34(4).