MRI abnormalities and related risk factors of the brain in patients with neuromyelitis optica
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 3
- DOI:
- 10.3760/cma.j.issn.1005-1201.2011.03.003
- Key Word:
- 视神经脊髓炎;磁共振成像;脑;Neuromyelitis optica;Magnetic resonance imaging;Brain
Abstract： Objective To investigate the MRI features of the brain in patients with neuromyelitis optica (NMO), and to evaluate the correlation between the brain abnormalities and related risk factors.Methods Fifty-four patients with definite NMO according to 2006 Wingerchuk diagnosis criteria were enrolled in this study. MRI scanning of the brain was performed in these patients. Distribution and signalfeatures of all the lesions were analyzed. A Logistic regression analysis was used to evaluate the risk factors of brain abnormalities. Results Twenty-four NMO patients (44. 4%) showed unremarkable findings and thirty (55.6%) showed abnormalities on brain MRI. Multiple and non-specific small lesions in the subcortical white matter and grey-white matter junction were the most frequent abnormalities on brain MRI (13/30, 43. 3%). Typical lesion locations included corpus callosum, subependyma of ventricles,hypothalamus and brain stem. The lesions showed punctate, patchy and linear abnormal signals. Postcontrast MRI showed no abnormal enhancement in 16 cases. Logistic regression analysis showed that coexisting anto-immune disease or infection history had correlations with abnormalities of the brain on MRI (OR=3.519,P ＜0.05). Conclusions There was a high incidence of brain abnormalities in NMO.Subependymal white matter, corpus callosum, hypothalamus and brain stem were often involved in NMO.NMO patients with coexisting anto-immune disease and infection history had higher risk of brain abnormalities.
- [1]D M, Wingerchuk,W F, Hogancamp,P C, O'Brien,etc.The clinical course of neuromyelitis optica (Devic's syndrome).[J].1999,53.
- [2]Lennon VA,Kryzer TJ,Pittock SJ,etc.IgG marker of optic-spinal multiple sclerosis binds to the aquaporin-4 water channel.[J].2005,202(4).
- [3]Wingerchuk DM,Lennon VA,Lucchinetti CF,etc.The spectrum of neuromyelitis optica.[J].2007,6(9).
- [4]F, Barkhof,M, Filippi,D H, Miller,etc.Comparison of MRI criteria at first presentation to predict conversion to clinically definite multiple sclerosis.[J].1997,120 ( Pt 11).
- [5]Kim BJ,Kim BJ,Vincent A,etc.Brain abnormalities in Sjogren syndrome with recurrent CNS manifestations: association with neuromyelitis optica.[J].2009,15(9).
- [6]Weinshenker BG,Lucchinetti CF,Pittock SJ,etc.Neuromyelitis optica brain lesions localized at sites of high aquaporin 4 expression.[J].2006,63(7).
- [7]Roemer SF,Parisi JE,Lennon VA,etc.Pattern-specific loss of aquaporin-4 immunoreactivity distinguishes neuromyelitis optica from multiple sclerosis.[J].2007,130(Pt.5).
- [8]Binder DK,Bloch O,Papadopoulos MC,etc.Three distinct roles of aquaporin-4 in brain function revealed by knockout mice[J].2006,1758(8).
- [9]Filippi M,Falini A,Arnold DL,etc.Magnetic resonance techniques for the in vivo assessment of multiple sclerosis pathology: Consensus report of the white matter study group.[J].2005,21(6).
- [10]Poppe AY,Lapierre Y,Melancon D,etc.Neuromyelitis optica with hypothalamic involvement.[J].2005,11(5).
- [11]Lennon VA,Wingerchuk DM,Kryzer TJ,etc.A serum autoantibody marker of neuromyelitis optica: distinction from multiple sclerosis.[J].2004,364(9451).
- [12]Wingerchuk DM,Lennon VA,Pittock SJ,etc.Revised diagnostic criteria for neuromyelitis optica.[J].2006,66(10).
- [13]J F, Kurtzke.Rating neurologic impairment in multiple sclerosis: an expanded disability status scale (EDSS).[J].1983,33.
- [14]Nakamura M,Fujihara K,Misu T.Occurrence of acute large and edematous callosal lesions in neuromyelitis optica.[J].2009,15(6).