Correlation between CT perfusion and vascular endothelial growth factor in neoplasm of head and neck
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 9
- DOI:
- 10.3760/j.issn:1005-1201.2007.09.003
- Key Word:
- 头颈部肿瘤;体层摄影术,X线计算机;病理学
Abstract： 目的 研究头颈部肿瘤CT灌注与肿瘤血管生成因子(VEGF)的相关性.方法 对85例共88个(恶性77个,良性11个)头颈部肿瘤术前行CT灌注检查.采用螺旋CT机自带软件绘制感兴趣区(ROI)的时间-密度曲线(TDC)并计算ROI强化峰值(PH)、达峰时间(PT)、平均通过时间(MTT),病灶相对强化峰值(RPH)和灌注量(PF).其中35例切取与CT灌注靶层面相同的组织切片,行CD34、VEGF抗体免疫组织化学染色,分析肿瘤CT灌注成像表现与微血管密度(MVD)和VEGF表达的相关性.结果 (1)头颈部肿瘤CT灌注成像TDC主要有3种类型,77个恶性肿瘤中53个(68.9%)表现为速升速降型;9个淋巴瘤中6个TDC表现为低平型曲线,与68个其他肿瘤中仅有9个为低平型曲线相比差异有统计学意义(P＜0.05).(2)甲状腺癌呈高灌注,其PF(中位数为82.2 ml·min-1·100 g-1)与淋巴瘤PF(中位数为24.5 ml·min-1·100 g-1)、头颈鳞癌PF(中位数为23.8ml·min-1·100 g-1)相比差异有统计学意义(P＜0.05).(3)11个良性肿瘤的MVD均数为(44.7±3.4)条/高倍视野,24个恶性肿瘤的MVD为(49.6±14.8)条/高倍视野,良恶性肿瘤间差异无统计学意义(P＞0.05);VEGF在恶性肿瘤呈强阳性者15个,弱阳性9个;在良性肿瘤呈强阳性1个,弱阳性10个,VEGF的表达强阳性率在良、恶性肿瘤差异有统计学意义(P＜0.01).(4)MVD(中位数40.0)与PH(中位数26.9)、RPH(中位数14.5)和PF(中位数46.8)有明显相关性(r值分别为0.35、45.49和0.41),VEGF(中位数4.0)表达与MTT(中位数16.7)呈负相关(r=-0.41).结论 CT灌注成像TDC形态对头颈部肿瘤诊断及鉴别诊断有一定的帮助.MVD、VEGF与CT灌注相关,CT灌注成像可以反映肿瘤微循环情况.
- [1]陈卫霞,闵鹏秋,宋彬,等.肝细胞癌螺旋CT同层动态扫描表现与肿瘤血管生成的相关性[J].2001,(4).
- [2]孟悛非,张朝晖,黄兆民.CT动态增强扫描在肌肉骨骼系统良恶性肿物鉴别中的价值[J].1999,(9).
- [3]Zi-Ping Li,Quan-Fei Meng,Can-Hui Sun,etc.Tumor angiogenesis and dynamic CT in colorectal carcinoma: Radiologic-pathologic correlation[J].2005,(9).
- [4]孙灿辉,孟悛非,李子平,等.结直肠癌血管内皮生长因子与螺旋CT灌注成像的相关性[J].2006,(2).
- [5]梁颖,罗德红,吴宁,等.颈部恶性淋巴结的多层螺旋CT灌注研究[J].2004,(11).
- [6]孟悛非,吕衍春,吕凤华,等.增强MR灌注成像在骨骼-软组织肿瘤良恶性鉴别诊断中的价值[J].2001,(8).
- [7]伍建林,李光军,王克礼,等.多层螺旋CT灌注成像鉴别诊断肺癌与肺良性肿物[J].2005,(4).
- [8]薛彩霞,王绍武,袁飞,等.软组织肿瘤的多层螺旋CT、MR灌注成像初步研究[J].2004,(11).
- [9]李传亭,吕玉波,张东生,等.多层螺旋CT灌注成像评价颌面部肿瘤微血管密度的研究[J].2005,(8).
- [10]生晶,田建明,邢伟,等.MSCT灌注成像对淋巴结转移瘤的鉴别诊断和疗效评价的临床研究[J].2005,(7).
- [11]M, Volm,R, Koom?gi,J, Mattern.Prognostic value of vascular endothelial growth factor and its receptor Flt-1 in squamous cell lung cancer.[J].1997,74.
- [12]Van den Bogaert W,Hermans R,Meijerink M,etc.Tumor perfusion rate determined noninvasively by dynamic computed tomography predicts outcome in head-and-neck cancer after radiotherapy.[J].2003,57(5).
- [13]A, Cenic,D G, Nabavi,R A, Craen,etc.Dynamic CT measurement of cerebral blood flow: a validation study.[J].1999,20.
- [14]J, Dunst,P, Stadler,A, Becker,etc.Tumor hypoxia and systemic levels of vascular endothelial growth factor (VEGF) in head and neck cancers.[J].2001,177.
- [15]Zhang M,Kono M.Solitary pulmonary nodules: evaluation of blood flow patterns with dynamic CT.[J].1997,205(2).
- [16]Nishihara H,Abe K,Watanabe S,etc.Tumor angiogenesis and dynamic CT in lung adenocarcinoma: radiologic-pathologic correlation.[J].2001,25(1).
- [17]Yamashita K,Patz EF,Midthun DE,etc.Lung nodule enhancement at CT: multicenter study.[J].2000,214(1).
- [18]Fournier L,Balvay D,Cuenod CA,etc.Tumor angiogenesis: pathophysiology and implications for contrast-enhanced MRI and CT assessment.[J].2006,31(2).
- [19]J M, Wang,S, Kumar,D, Pye,etc.Breast carcinoma: comparative study of tumor vasculature using two endothelial cell markers.[J].1994,86.
- [20]Provenzale JM,Eastwood JD.Cerebral blood flow, blood volume, and vascular permeability of cerebral glioma assessed with dynamic CT perfusion imaging.[J].2003,45(6).
- [21]Zerhouni EA,McCarthy EF,Ma LD,etc.Benign and malignant musculoskeletal masses: MR imaging differentiation with rim-to-center differential enhancement ratios.[J].1997,202(3).
- [22]Jeon HS,Son JW,Park TI,etc.Vascular endothelial growth factor gene polymorphisms and risk of primary lung cancer.[J].2005,14(3).
- [23]Y, Boucher,M, Leunig,R K, Jain.Tumor angiogenesis and interstitial hypertension.[J].1996,56.