Diffusion tensor imaging of brain in relapsing neuromyelitis optica
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 6
- DOI:
- 10.3760/j.issn:1005-1201.2007.06.005
- Key Word:
- 视神经脊髓炎;脑损害,慢性;磁共振成像
Abstract： 目的 利用扩散张量成像(DTI)探讨复发性视神经脊髓炎(RNMO)患者是否存在隐匿性脑组织损伤及其发生机制.方法 对16例RNMO患者和16例性别和年龄匹配的正常志愿者脑组织的平均扩散系数(MD)和部分各向异性(FA)进行直方图和感兴趣区(ROI)分析,以P≤0.005为差异有统计学意义.结果 与志愿者比较,RNMO患者脑的平均MD升高[脑组织:RNMO患者(0.95±0.02)×10-3 mm2/s,志愿者(0.91±0.03)×10-3 mm2/s,t=3.940,P＜0.001;脑白质:RNMO患者(0.82±0.02)×10-3 mm2/s,志愿者(0.80±0.02)×10-3 mm2/s,t=3.117,P=0.004;脑灰质:RNMO患者(1.06±0.04)×10-3 mm2/s,志愿者(0.88±0.05)×10-3 mm2/s,t=4.031,P＜0.001]、脑白质的FA直方图峰高抬高[RNMO患者(2.61±0.18)‰,志愿者(2.38±0.18)‰,t=3.627,P=0.001]及脑灰质的MD直方图峰高降低[RNMO患者(7.37±0.89)%,志愿者(8.91±1.71)‰,t=3.210,P=0.003]和峰位置抬高[RNMO患者(0.83±0.02)×10-3 mm2/s,志愿者(0.81±0.02)×10-3 mm2/s,t=4.373,P＜0.001];与脊髓和视神经有直接联系ROI的平均MD升高[延髓:RNMO患者(1.27±0.11)×10-3 mm2/s,志愿者(1.11±0.10)×10-3 mm2/s,t=4.260,P＜0.001;大脑脚:RNMO患者(1.01±0.11)×10-3 mm2/s,志愿者(0.87±0.05)×10-3 mm2/s,t=4.391,P＜0.001;内囊:RNMO患者(0.74±0.01)×10-3 mm2/s,志愿者(0.72±0.01)×10-3 mm2/s,t=4.683,P＜0.001;视放射:RNMO患者(0.88±0.03)×10-3 mm2/s,志愿者(0.82±0.03)×10-3 mm2/s,t=4.619,P＜0.001)、平均FA降低(延髓:RNMO患者0.27±0.01,志愿者0.29±0.03,t=2.996,P=0.005;大脑脚:RNMO患者0.49±0.04,志愿者0.54±0.03,t=4.280,P＜0.001;内囊:RNMO患者0.66±0.02,志愿者0.69±0.02,t=3.953,P＜0.001;视放射:RNMO患者0.53±0.04,志愿者0.59±0.03,t=4.705,P＜0.001);而与脊髓和视神经无直接联系的胼胝体的平均MD[膝部:RNMO患者(0.76±0.04)×10-3 mm2/s,志愿者(0.73±0.03)×10-3 mm2/s;压部:RNMO患者(0.77±0.05)×10-3 mm2/s,志愿者(0.73±0.04)×10-3 mm2/s]和FA值(膝部:RNMO患者0.82±0.03,志愿者0.82±0.03;压部:RNMO患者0.83±0.03,志愿者0.83±0.02)差异无统计学意义(P值均＞0.005).结论 RNMO患者存在隐匿性脑组织损伤,这可能与继发于脊髓和视神经病灶的顺行和逆行性变性有关.
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