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Application of functional MRI in breast diseases
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1005-1201.2007.05.003
- Key Word:
- 乳腺疾病;磁共振成像;评价研究
Abstract： 目的 研究功能MR成像(fMRI)在乳腺疾病诊断与鉴别诊断中的价值.方法 对65例患者共计68个病灶进行fMRI检查,所有病例均经手术病理证实.扫描序列包括T1 WI与T2 WI平扫、动态增强、扩散加权成像(DWI)与单体素1H波谱分析.分析病灶的形态学特征;根据动态增强绘制时间-信号曲线,计算最大强化率;根据扩散加权统计表观扩散系数(ADC);当发现病灶时进行波谱分析,并将胆碱峰视为乳癌阳性发现.结果 T1 WI与T2 WI的病灶检出率分别为14.7%(10个)与51.5%(35个).而动态增强序列对恶性肿瘤的敏感性为94.6%(35/37),特异性为71.4%(35/49),诊断正确率为76.5%(52/68).回顾性研究表明,扩散敏感因子(b)值为800～1000 s/mm2时,DWI能够很好地鉴别各类病灶.单体素质子波谱分析的敏感性为51.4%(19/37),特异性为82.6%(19/23),诊断正确率为67.6%(46/68).MR平扫、动态增强与MRS相结合的联合诊断对乳腺恶性肿瘤的敏感性为97.3%(36/37),特异性为90.0%(36/40),诊断正确率为92.6%(63/68).结论 fMRI对乳腺恶性肿瘤的敏感性、特异性与诊断正确率均较高,有着广阔的应用前景.
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