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Correlation study between MR spectroscopic findings and cell proliferation in astrocytoma
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1005-1201.2007.04.004
- Key Word:
- 磁共振波谱学;星形细胞瘤;增殖细胞核抗原;免疫组织化学
Abstract： 目的 探讨星形细胞瘤质子MR波谱(1H-MRS)表现与肿瘤增殖潜力的相关性.方法 术前进行MRI和1H-MRS检查且经手术病理证实的34例星形细胞瘤患者,其中Ⅰ、Ⅱ级(低级别)26例,Ⅲ、Ⅳ级(高级别)8例.34例星形细胞瘤患者中有21例(低级别17例,高级别4例)为均质性肿瘤.增殖细胞核抗原(PCNA)免疫组织化学染色,研究PCNA在高、低级别星形细胞瘤中的表达水平,并与星形细胞瘤1H-MRS的胆碱(Cho)/N-乙酰天冬氨酸(NAA)、Cho/肌酸和磷酸肌酸(Cr)相比较,明确两者间的关系.结果 21例均质性肿瘤中,高级别星形细胞瘤的Cho/NAA、Cho/Cr(中位数分别为4.895、4.845)比低级别(中位数分别为2.920、2.000)明显升高(Z=-2.597,P=0.009;Z=-2.687,P=0.007);且Cho/NAA、Cho/Cr与PCNA的表达[吸光度(A)值中位数7.880]呈明显正相关(r=0.607,P=0.003;r=0.457,P-0.038).但全部34例星形细胞瘤中高、低级别Cho/NAA(中位数分别为3.965、2.890)、Cho/Cr(分别为3.080、1.960)的差异无统计学意义;Cho/NAA、Cho/Cr的比值与PCNA的表达(A值中位数为8.100)不相关(r=0.060,P=0.738;r=0.125,P=0.480).结论 运用1H-MRS检测均质性星形细胞瘤中Cho的含量对于术前活体预测星形细胞瘤的恶性程度很有价值,从而能间接判断星形细胞瘤的某些生物学行为及预后.
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