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Bold-functional MRI study of the abnormal cortex and the relationship between the inpairment of vision and the decreased activation of the visual cortex in anisometropic amblyopia
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 12
- DOI:
- 10.3760/j.issn:1005-1201.2006.12.003
- Key Word:
- 弱视;大脑皮质;磁共振成像
Abstract： 目的 利用血氧水平依赖性功能MRI(BOLD-fMRI)技术,探讨屈光参差性弱视患者不同分区的大脑视觉皮层功能的影响,分析皮层激活改变与视力损害间的可能关系.方法 以1.5TMR成像系统采集10例屈光参差性弱视患者枕叶视皮层兴趣区BOLD-fMRI数据,比较屈光参差性弱视组弱视眼与对侧眼及弱视眼屈光矫正前、后皮层激活范围的不同,分析其改变特点及机制.测定弱视眼视力损害情况,分析其与皮层激活改变的可能关系.统计分析采用配对样本秩和检验方法.结果 弱视眼裸眼平均皮层激活范围为(3.7±0.4)×104体素,矫正后为(4.1±0.5)×104体素,差异有统计学意义(Z=-2.197,P=0.028).戴眼镜矫正视力后,弱视眼Brodmann 17区皮层激活范围为(0.44±0.07)×104体素,对侧眼为(0.47±0.07)×104体素,弱视眼Brodmann 18、19区皮层激活范围为(3.7±0.3)×104体素,对侧眼为(3.4±0.4)×104体素,差异均有统计学意义(Z值分别为-2.050、-2.524,P值分别为0.040、0.012).弱视者双眼皮层激活差异指数为0.05±0.04,双眼视力差异指数为0.58±0.22,二者无线性相关性(r＝0.35,P＝0.40).结论 屈光参差性弱视各级视觉皮层均发生了明显的激活范围改变,弱视眼矫正屈光不正后皮层激活范围明显增大,提示尽早矫正视力对改善弱视皮层损害有帮助,但这种皮层激活范围的改变与视力的损害情况间并不呈线性相关.
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