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Functional MRI study of verbal working memory in children with attention deficit hyperactivity disorder
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1005-1201.2006.11.002
- Key Word:
- 注意力缺陷和分裂性行为障碍;磁共振成像;儿童
Abstract： 目的 研究注意缺陷多动障碍(ADHD)儿童在语义工作记忆任务下不同脑区的功能状态.方法 ADHD儿童与正常学龄儿童各9名,分别进行行为学评估和功能MR(fMR)扫描,刺激任务采用区组(BLOCK)设计的倒退N计数(N-BACK)模式下语义工作记忆任务.fMR扫描采用GE 3.0 T MR记录提取阶段大脑的反应.结果 ADHD儿童在语义工作记忆任务下激活普遍低于正常组,在1-BACK任务中双侧额中回、额下回、双侧顶上小叶、顶下小叶、右基底节激活低于正常组,而在2-BACK任务中双侧额中回、额下回、双侧顶上小叶、左侧顶下小叶、右基底节及前扣带回激活低于正常组.结论 ADHD儿童的工作记忆功能区包括双侧背外侧前额叶及双侧顶叶存在功能低下,在高负荷的2-BACK任务下并有执行功能区(前扣带回)的激活降低.
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