Study of acupuncture point Liv 3 with functional MRI
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1005-1201.2006.01.008
- Key Word:
- 针刺;磁共振成像;脑
Abstract： 目的采用功能MRI(fMRI)方法研究与针刺太冲穴(Liv3)有关的脑功能区,以及可能的针刺后效应.方法健康右利手志愿者18例参加本次实验.实验采用单组块设计,包括静息期、刺激期和针刺后效应期.每名被试只接受1种针刺,即针刺右侧Liv3或针刺相邻假穴位,其中,10例被试者参加穴位针刺,其余8例参加假穴位针刺,同时进行全脑的fMRI.采用统计参数图(SPM99)进行统计学分析,用t检验分析获得刺激期、后效应期状态分别与静息期状态信号对比的脑功能图像,以P<0.001的像素构成统计参数图,最后利用SPM的掩盖(Mask)功能,从针刺激活区中排除假穴位针刺的干扰激活区,得出针刺激活的特异性脑区图.结果排除8例假穴位针刺期激活脑区后,与静息状态比较,针刺10例被试右侧太冲穴激活的脑区主要包括左右小脑(t值分别为10.06、9.82)、前额叶、顶上小叶(t值分别为4.36、4.53)和顶下小叶(t值分别为3.94、4.95)、枕叶、海马旁回(t值分别为5.63、6.32)、岛叶(t值分别为3.82、5.51)、丘脑、豆状核(t值分别为3.24、4.40)以及对侧颞极和前、后扣带回(P值均<0.01).排除8例假穴位针刺"后效应期"激活区后,针刺10例被试太冲穴后效应期激活的脑区主要包括双侧小脑、前额叶、顶上小叶和顶下小叶、枕叶、豆状核、海马旁回,同侧颞极、海马、岛叶和丘脑,对侧尾状核头和胼胝体以及前、后扣带回.结论针刺Liv3激活视区、边缘系统和皮层下灰质结构,可能是脑内调整的特异性脑区,而且这些区域在后效应期仍有激活,为针刺后效应的存在提供了一定的客观证据,这将为以后针刺实验的科学设计奠定基础工作.
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