The age-related changes of normal adult brain structure: analysis with diffusion tensor imaging
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 1
- DOI:
- 10.3760/j.issn:1005-1201.2006.01.007
- Key Word:
- 脑;年龄因素;磁共振成像,弥散;各向异性
Abstract： 目的应用扩散张量成像(diffusion tensor imaging, DTI)定量测定正常成人脑的各向异性及平均扩散系数(average diffusion coefficient, DCavg)的变化,以反映脑显微结构随年龄增长的变化.方法对106例正常成人行DTI,测定脑不同解剖部位的部分各向异性(fractional anisotropy,FA)、1-容积比(1-volume ratio,1-VR)、相对各向异性(relative anisotropy,RA)和DCavg,分别对各参数与年龄进行相关性分析,且进行各组间比较.结果胼胝体膝部(FA:r＝-0.491, P=0.000;1-VR:r＝-0.508,P=0.000,RA:r＝-0.494, P=0.000;DCavg:r＝0.263,P=0.006)、压部(FA:r＝-0.569,P=0.000;1-VR:r＝-0.531,P=0.000;RA:r＝-0.535,P=0.000;DCavg:r＝0.475,P=0.000)、半卵圆中心(FA:r＝-0.562, P=0.000;1-VR:r＝-0.588,P=0.000;RA:r＝-0.561,P=0.000;DCavg:r＝0.337, P=0.000)、丘脑(FA:r＝-0.210, P=0.031;1-VR:r＝-0.203,P=0.036;RA:r＝-0.213, P=0.028;DCavg:r＝0.354,P=0.000)等的FA、1-VR、RA与年龄呈负相关,其DCavg与年龄呈显著性正相关.而豆状核的FA、1-VR、RA及DCavg(FA:r＝0.287,P=0.003;1-VR:r＝0.290,P=0.003;RA:r＝0.283,P=0.003;DCavg:r＝0.325,P=0.001)均随年龄增长而增加.结论 DTI可无创性反映随年龄的增长脑的显微结构发生的变化.
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