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Initial functional MR imaging study of the motor hand area in brain metastases with gamma knife treatment
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 10
- DOI:
- 10.3760/j.issn:1005-1201.2005.10.002
- Key Word:
- 磁共振成像;脑;肿瘤转移;放射外科手术
Abstract： 目的探讨应用功能MR成像(fMRI)指导脑转移瘤伽玛刀剂量计划时保护手运动区的价值.方法 10例毗邻手运动区的脑转移瘤患者行fMRI检查.剂量计划时,参考功能图像使手运动区所覆盖的等剂量曲线值低于30%.结果所有病例均有中央沟变形、伸长和移位,手运动区变形.9例病灶同侧活动指数(IAI)＜1,1例IAI＞1,中位数为0.51,9例患侧信号强度上升百分率(SIRP)为2.70,较健侧4.32低(Z=-2.248, P=0.025).治疗后随访,9例患侧手肌力逐渐恢复,治疗后3个月IAI 1.27(Z=-2.197,P=0.028)、SIRP 5.22(Z=-2.807, P=0.005)以及治疗后6个月IAI 1.39(Z=-2.366,P=0.018)、SIRP 5.69(Z=-2.701,P=0.007)均大于伽玛刀治疗前,两者间变化差异有统计学意义.结论初步研究表明fMRI指导放射外科剂量计划,保护脑运动区.
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