You Position: Home > Paper
Clinical application of diffusion tensor imaging in acute stroke
( views:504, downloads:400 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 7
- DOI:
- 10.3760/j.issn:1005-1201.2005.07.001
- Key Word:
- 脑梗死;磁共振成像;扩散;白质纤维束
Abstract： 目的应用MR扩散张量成像(DTI)技术对急性脑梗死行动态观察,研究其扩散变化规律,推断缺血半暗带的治疗时间窗,并通过扩散张量纤维束成像(DTT)技术论证皮质脊髓束与肌力的相关关系.方法对71例不同时间窗的脑梗死病例行常规MRI、扩散加权成像(DWI)及DTI检查,测定各期病灶的平均扩散系数(DCavg)、部分各向异性系数(FA)、相对各向异性系数(RA)及容积比(1-VR)值,并对10例行三维白质纤维重建.结果梗死不同时期的DCavg均值分别为[(0.275±0.022),(0.349±0.019),(0.465±0.023),(0.538±0.035)]×10 -3 mm 2/s,随时间变化呈明显减低、逐渐回升、假正常化的趋势(P<0.001);FA、RA、1-VR值在超急性期轻度升高,以后呈不可复性减低的趋势;超急性期、急性期病灶中心区与边缘区的DCavg、FA、RA、1-VR值差异有统计学意义(P<0.001).皮质脊髓束表现为无受压、受压无中断及中断、破坏,其临床肌力表现为无减退、治疗后肌力恢复、无恢复.结论梗死灶的DCavg、FA、RA、1-VR值具有特征性演变规律;超急性期、急性期病灶边缘区可能为缺血半暗带组织,其治疗时间窗可扩展为24 h.DTT技术对临床及判断预后有重要价值.
- [1]高培毅,梁晨阳,林燕,等.脑梗死前期脑局部微循环障碍CT灌注成像的实验研究[J].2003,(8).
- [2]T. Adrian Carpenter,Christopher L.-H. Huang,Laurance D. Hall,etc.A Comparative Study of Acquisition Schemes for Diffusion Tensor Imaging Using MRI[J].1999,137(1).
- [3]S, Warach,M, Boska,K M, Welch.Pitfalls and potential of clinical diffusion-weighted MR imaging in acute stroke.[J].1997,28.
- [4]Sorensen AG,Wedeen VJ,Copen WA,etc.Human acute cerebral ischemia: detection of changes in water diffusion anisotropy by using MR imaging.[J].1999,212(3).
- [5]Ulug A. M.,Beauchamp N.,Bryan R. N.,etc.Absolute Quantitation of Diffusion Constants in Human Stroke[J].1997.
- [6]Atlas SW,Tuhrim S,Singer MB,etc.Diffusion-weighted MRI in acute subcortical infarction (published erratum appears in Stroke 1998 Mar; 29(3):731) (see comments)[J].1998,29(1).
- [7]Gillard JH,Warburton EA,Carpenter TA,etc.Increased anisotropy in acute stroke: a possible explanation.[J].2002,33(6).
- [8]Tress BM,Darby DG,Li T,etc.Serial study of apparent diffusion coefficient and anisotropy in patients with acute stroke.[J].1999,30(11).
- [9]Eagle S,Semple J,Strugnell W,etc.An evaluation of the time dependence of the anisotropy of the water diffusion tensor in acute human ischemia.[J].1999,17(3).
- [10]Le-Bihan D,Mangin JF,Poupon C,etc.Diffusion tensor imaging: concepts and applications.[J].2001,13(4).
- [11]Lie C,Hennerici MG,Gass A,etc.Clinicotopographical correlation of corticospinal tract stroke: a color-coded diffusion tensor imaging study.[J].2004,35(1).
- [12]Parker GJ,Werring DJ,Barker GJ,etc.Diffusion tensor imaging can detect and quantify corticospinal tract degeneration after stroke.[J].2000,69(2).