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Visual attention deficits in Alzheimer's disease--a fMRI study
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 5
- DOI:
- 10.3760/j.issn:1005-1201.2005.05.001
- Key Word:
- 磁共振成像;刺激;视觉;阿尔茨海默病
Abstract： 目的采用功能磁共振成像(functional MRI, fMRI)技术考察Alzheimer病(AD)视觉注意缺陷的原因,并对其相应的神经解剖基础进行初步探讨.方法 13例临床诊断可能为AD的患者和13例年龄、性别与之相匹配的健康老年人参加了2种不同视觉搜索的实验测试(即联合特征搜索和子集搜索任务:其中的靶刺激均具有2个特征,但前者是通过特征捆绑策略,后者是通过项目分组形成子集来完成任务).同时采用Siemens Sonata 1.5 T成像系统, 采集其脑部fMRI数据,通过功能神经成像分析软件SPM 99 (statistical parametric mapping software, SPM)进行统计分析得到脑功能活动的图像.结果尽管2个研究组在完成不同搜索任务时的脑区大部分相互重叠,包括顶叶、额叶、颞枕交界区、原始视皮层和皮层下结构等脑区,但不同脑区的激活强度和范围明显不同,AD组主要表现为双侧顶叶和左侧额叶激活减少,并以子集搜索任务时的组间差异更显著.结论 AD患者在项目分组和特征捆绑方面均存在一定程度功能失调,其视觉注意缺陷可能是由于顶叶病变使注意焦点在不同空间位置转换困难所致,同时伴有前扣带回和前额叶功能不良.
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