You Position: Home > Paper
The experimental research on rabbit models of corticosteroid-induced avascular necrosis of femoral head
( views:263, downloads:8 )
- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 4
- DOI:
- 10.3760/j.issn:1005-1201.2005.04.007
- Key Word:
- 股骨头坏死;糖皮质激素类;兔;动物,实验
Abstract： 目的探讨激素性股骨头坏死(ANFH)的病理发展过程及早期影像学表现.方法运用ANFH模型25只,随机(数字法)分为5组,与对照组进行比较,分别观察注射4、6、8、10、12周股骨头病理组织学和影像学改变. 结果 ANFH最早变化发生在骨髓,然后为骨小梁.在给药4、6、8、10、12周时,数字X线摄影(DR)检查分别有0、0、0、2、2只兔股骨头可见斑片状密度减低影;CT分别有0、0、1、2、4只兔股骨头可见囊状透亮区和斑片状密度减低影;MRI分别有0、3、5、5、5只兔股骨头在T1WI呈不规则低信号,T2WI呈低信号或高信号 .结论 ANFH的影像学表现与病理变化密切相关,MRI是诊断ANFH最敏感的方法.
- [1]R L, Cruess.Osteonecrosis of bone. Current concepts as to etiology and pathogenesis.[J].1986,(208).
- [2]J P, Jones.Fat embolism and osteonecrosis.[J].1985,16(4).
- [3]Razi A,Plancher KD.Management of osteonecrosis of the femoral head.[J].1997,28(3).
- [4]R L, Cruess.Steroid-induced osteonecrosis: a review.[J].1981,24.
- [5]L, Solomon.Bone-marrow oedema syndrome.[J].1993,75(2).
- [6]M, Matsui,S, Saito,K, Ohzono,etc.Experimental steroid-induced osteonecrosis in adult rabbits with hypersensitivity vasculitis.[J].1992,(277).
- [7]C J, Glueck,R, Freiberg,T, Tracy,etc.Thrombophilia and hypofibrinolysis: pathophysiologies of osteonecrosis.[J].1997,(334).