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Volumetric MRI analysis of the amygdala and the hippocampus in patients with major depression
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1005-1201.2005.02.006
- Key Word:
- 抑郁症;海马;杏仁核;磁共振成像
Abstract： 目的探讨抑郁症患者海马及杏仁核容积改变特点.方法研究22例抑郁症患者及13例健康志愿者,运用MRI容积分析软件测量两侧海马及杏仁核容积.结果抑郁症患者及对照组均显示两侧海马容积不对称(左侧＜右侧;抑郁组:t=21.80, P<0.01;对照组:t=24.90, P<0.01);抑郁症患者两侧海马容积比对照组有明显减小(左侧:t= 9.96, P<0.01;右侧:t=11.88, P<0.01);右侧杏仁核明显小于对照组(t=5.50, P<0.01);抑郁症患者海马容积缩小与病程缺乏相关性.结论海马及杏仁核容积异常可能构成抑郁症的神经生物学基础,也说明边缘系统在抑郁症的发病机理中起着重要作用.
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