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The preliminary study of CT cerebral perfusion imaging on the brain injury of the high +Gx in Rhesus
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 2
- DOI:
- 10.3760/j.issn:1005-1201.2005.02.003
- Key Word:
- 缺氧缺血,脑;航天医学;体层摄影术,X线计算机;动物,实验
Abstract： 目的探讨CT脑灌注成像对胸背向过载过载(+Gx)作用下猴脑部损伤的诊断价值.方法 7只健康雄性成年恒河猴随机表法随机分为对照组(2只)和+15 Gx组(5只),+15 Gx组在动物离心机上承受+15 Gx峰值的抛物线形过载曲线作用;应用CT脑灌注成像分别观察+Gx作用前和作用后2 h、24 h、1周后猴脑血流的改变,同时行病理(光学显微镜、电子显微镜)检查.结果+15 Gx过载作用后2 h、24 h大脑呈缺血性改变,1周后血流灌注基本恢复正常;光学显微镜下显示大脑皮层锥体细胞出现轻度的缺血性萎缩,电子显微镜下表现为核染色质聚集成团块状边集,胞质内线粒体嵴轻度紊乱.结论模拟飞船应急返回高过载可引起猴脑缺血性改变,CT脑灌注成像可提供有价值的诊断信息.
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