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The value of apparent diffusion coefficients (ADCs) in the diagnosis of malignant bone neoplasms
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- Author:
- No author available
- Journal Title:
- CHINESE JOURNAL OF RADIOLOGY
- Issue:
- 11
- DOI:
- 10.3760/j.issn:1005-1201.2004.11.003
- Key Word:
- 骨肿瘤;磁共振成像;病理学;对比研究
Abstract： 目的 评价表观扩散系数(ADC)值在原发性恶性骨肿瘤诊断中的价值.方法 前瞻性对照分析18例膝周恶性原发性骨肿瘤患者的术前MR单次激励平面回波扩散加权成像(MRSSEPI-DWI)和术后标本定点取材的病理资料.计算肿瘤实质、瘤周水肿组织、肿瘤坏死部位及正常肌肉和骨髓组织的ADC值.结果 恶性骨肿瘤肿瘤实质(骨内部分及骨外软组织肿块部分)、瘤周水肿肌肉、瘤周水肿骨髓、肿瘤坏死及正常肌肉和正常骨髓组织的ADC值分别为[(1.181±0.236)×10-3mm2/s(骨内部分)和(1.158±0.259)×10-3mm2/s(骨外部分)]、(2.347±0.233)×10-3mm2/s、(1.997±0.119)×10-3mm2/s、(2.230±0.208)×10-3mm2/s、(0.486±0.313)×10-3mm2/s和(0.483±0.288)×10-3mm2/s.各不同组织间ADC值的差异有显著性学意义(F=153.131,P=0.000).其中,肿瘤实质(骨内部分及骨外肿块部分)的ADC值高于正常肌肉(P<0.05)及正常骨髓组织(P<0.05),低于水肿肌肉及水肿骨髓组织(P<0.05),也低于肿瘤坏死部位(P<0.05). 结论 通过MR-SSEPI-DWI 计算ADC值的方法,可以定量分析鉴别恶性骨肿瘤的肿瘤实质与瘤周水肿、肿瘤实质与肿瘤坏死部位,从而为确定肿瘤实质的实际浸润范围及估计化疗后肿瘤坏死体积提供依据.
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